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Combined assessment...
Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome
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Costa, Jason (författare)
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Lopes, Coeli M. (författare)
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Barsheshet, Alon (författare)
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Moss, Arthur J. (författare)
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Migdalovich, Dmitriy (författare)
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Ouellet, Gregory (författare)
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McNitt, Scott (författare)
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Polonsky, Slava (författare)
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Robinson, Jennifer L. (författare)
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Zareba, Wojciech (författare)
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Ackerman, Michael J. (författare)
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Benhorin, Jesaia (författare)
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Kaufman, Elizabeth S. (författare)
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- Platonov, Pyotr (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Shimizu, Wataru (författare)
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Towbin, Jeffrey A. (författare)
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Vincent, G. Michael (författare)
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Wilde, Arthur A. M. (författare)
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Goldenberg, Ilan (författare)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Heart Rhythm. - : Elsevier BV. - 1547-5271. ; 9:6, s. 892-898
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND Men and women with type 1 long QT syndrome (LQT1) exhibit time-dependent differences in the risk for cardiac events. OBJECTIVE We hypothesized that sex-specific risk for LQT1 is related to the location and function of the disease-causing mutation in the KCNQ1 gene. METHODS The risk for life-threatening cardiac events (comprising aborted cardiac arrest [ACA] or sudden cardiac death [SCD]) from birth through age 40 years was assessed among 1051 individuals with LQT1 (450 men and 601 women) by the location and function of the LQT1-causing mutation (prespecified as mutations in the intracellular domains linking the membrane-spanning segments [ie, S2-S3 and S4-S5 cytoplasmic loops] involved in adrenergic channel regulation vs other mutations). RESULTS Multivariate analysis showed that during childhood (age group: 0-13 years) men had >2-fold (P < .003) increased risk for ACA/SCD than did women, whereas after the onset of adolescence the risk for ACA/SCD was similar between men and women (hazard ratio = 0.89 [P = .64]). The presence of cytoplasmic-loop mutations was associated with a 2.7-fold (P < .001) increased risk for ACA/SCD among women, but it did not affect the risk among men (hazard ratio 1.37; P = .26). Time-dependent syncope was associated with a more pronounced risk-increase among men than among women (hazard ratio 4.73 [P < .001] and 2.43 [P = .02], respectively), whereas a prolonged corrected QT interval (>= 500 ms) was associated with a higher risk among women than among men. CONCLUSION: Our findings suggest that the combined assessment of clinical and mutation location/functional data can be used to identify sex-specific risk factors for life-threatening events for patients with LQT1.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cytoplasmic-loop mutations
- Sex
- Long QT syndrome
- Sudden cardiac death
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Costa, Jason
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Lopes, Coeli M.
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Barsheshet, Alon
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Moss, Arthur J.
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Migdalovich, Dmi ...
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Ouellet, Gregory
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visa fler...
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McNitt, Scott
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Polonsky, Slava
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Robinson, Jennif ...
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Zareba, Wojciech
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Ackerman, Michae ...
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Benhorin, Jesaia
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Kaufman, Elizabe ...
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Platonov, Pyotr
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Shimizu, Wataru
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Towbin, Jeffrey ...
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Vincent, G. Mich ...
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Wilde, Arthur A. ...
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Goldenberg, Ilan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Heart Rhythm
- Av lärosätet
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Lunds universitet