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Mechanisms Underlyi...
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Hansen, Cerine C.Norwegian University of Science and Technology
(författare)
Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs : Focus on Topiramate, Levetiracetam, and Perampanel
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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Hindawi Limited,2018
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18 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:3eb16509-5252-41f2-aca5-33909fb423cc
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https://lup.lub.lu.se/record/3eb16509-5252-41f2-aca5-33909fb423ccURI
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https://doi.org/10.1155/2018/2064027DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk factors, and the underlying mechanisms of AB induced by AEDs may help to facilitate management and reduce the risk of such side effects. The exact incidence of AB as an adverse effect of AEDs is difficult to estimate, but frequencies up to 16% have been reported. Primarily, levetiracetam (LEV), perampanel (PER), and topiramate (TPM), which have diverse mechanisms of action, have been associated with AB. Currently, there is no evidence for a specific pharmacological mechanism solely explaining the increased incidence of AB with LEV, PER, and TPM. Serotonin (5-HT) and GABA, and particularly glutamate (via the AMPA receptor), seem to play key roles. Other mechanisms involve hormones, epigenetics, and "alternative psychosis" and related phenomena. Increased individual susceptibility due to an underlying neurological and/or a mental health disorder may further explain why people with epilepsy are at an increased risk of AB when using AEDs. Remarkably, AB may occur with a delay of weeks or months after start of treatment. Information to patients, relatives, and caregivers, as well as sufficient clinical follow-up, is crucial, and there is a need for further research to understand the complex relationship between AED mechanisms of action and the induction/worsening of AB.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ljung, HannaLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-hlj
(författare)
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Brodtkorb, EylertNorwegian University of Science and Technology,St. Olav’s University Hospital
(författare)
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Reimers, ArneLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)ar4172re
(författare)
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Norwegian University of Science and TechnologyNeurologi, Lund
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Behavioural Neurology: Hindawi Limited20180953-41801875-8584
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