SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:3f799aa9-8dc7-40af-9f10-5c2efe4e1fdb"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:3f799aa9-8dc7-40af-9f10-5c2efe4e1fdb" > Revisiting Diagnosi...

  • Ottaviani, AndreaUniversity G.d'Annunzio of Chieti-Pescara (författare)

Revisiting Diagnosis and Treatment of Hypertrophic Cardiomyopathy : Current Practice and Novel Perspectives

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:3f799aa9-8dc7-40af-9f10-5c2efe4e1fdb
  • https://lup.lub.lu.se/record/3f799aa9-8dc7-40af-9f10-5c2efe4e1fdbURI
  • https://doi.org/10.3390/jcm12175710DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:for swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Sarcomeric hypertrophic cardiomyopathy (HCM) is a prevalent genetic disorder characterised by left ventricular hypertrophy, myocardial disarray, and an increased risk of heart failure and sudden cardiac death. Despite advances in understanding its pathophysiology, treatment options for HCM remain limited. This narrative review aims to provide a comprehensive overview of current clinical practice and explore emerging therapeutic strategies for sarcomeric HCM, with a focus on cardiac myosin inhibitors. We first discuss the conventional management of HCM, including lifestyle modifications, pharmacological therapies, and invasive interventions, emphasizing their limitations and challenges. Next, we highlight recent advances in molecular genetics and their potential applications in refining HCM diagnosis, risk stratification, and treatment. We delve into emerging therapies, such as gene editing, RNA-based therapies, targeted small molecules, and cardiac myosin modulators like mavacamten and aficamten, which hold promise in modulating the underlying molecular mechanisms of HCM. Mavacamten and aficamten, selective modulators of cardiac myosin, have demonstrated encouraging results in clinical trials by reducing left ventricular outflow tract obstruction and improving symptoms in patients with obstructive HCM. We discuss their mechanisms of action, clinical trial outcomes, and potential implications for the future of HCM management. Furthermore, we examine the role of precision medicine in HCM management, exploring how individualised treatment strategies, including exercise prescription as part of the management plan, may optimise patient outcomes. Finally, we underscore the importance of multidisciplinary care and patient-centred approaches to address the complex needs of HCM patients. This review also aims to encourage further research and collaboration in the field of HCM, promoting the development of novel and more effective therapeutic strategies, such as cardiac myosin modulators, to hopefully improve the quality of life and outcome of patients with sarcomeric HCM.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Mansour, DavideUniversity G.d'Annunzio of Chieti-Pescara (författare)
  • Molinari, Lorenzo V.University G.d'Annunzio of Chieti-Pescara (författare)
  • Galanti, KristianUniversity G.d'Annunzio of Chieti-Pescara (författare)
  • Mantini, CesareUniversity G.d'Annunzio of Chieti-Pescara (författare)
  • Khanji, Mohammed Y.Newham University Hospital,Queen Mary University,Barts Health NHS Trust (författare)
  • Chahal, Anwar A.Barts Health NHS Trust,Hospital of the University of Pennsylvania (författare)
  • Zimarino, MarcoUniversity G.d'Annunzio of Chieti-Pescara (författare)
  • Renda, GiuliaUniversity G.d'Annunzio of Chieti-Pescara (författare)
  • Sciarra, LuigiUniversity of L'Aquila (författare)
  • Pelliccia, FrancescoSapienza University of Rome (författare)
  • Gallina, SabinaUniversity G.d'Annunzio of Chieti-Pescara (författare)
  • Ricci, FabrizioLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Ss Annunziata Hospital,University G.d'Annunzio of Chieti-Pescara(Swepub:lu)fa7062ri (författare)
  • University G.d'Annunzio of Chieti-PescaraNewham University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Medicine12:172077-0383

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy