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Photobleaching-Inse...
Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue
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- Brydegaard, Mikkel (författare)
- Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Department of Physics, Lund University
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- Haj-Hosseini, Neda (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT
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- Wårdell, Karin (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT
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- Andersson-Engels, Stefan (författare)
- Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Department of Physics, Lund University
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(creator_code:org_t)
- Institute of Electrical and Electronics Engineers, 2011
- 2011
- Engelska.
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Ingår i: IEEE Photonics Journal. - : Institute of Electrical and Electronics Engineers. - 1943-0655. ; 3:3, s. 407-421
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their applicability in a few examples from in vivo open brain surgery.
Ämnesord
- NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
Nyckelord
- Fluorescence-guided resection
- FGR
- 5-ALA
- PpIX
- protoporphyrin
- photobleaching
- laser-induced fluorescence spectroscopy
- LIF
- optical
- diagnostics
- tissue optics
- skin
- brain
- dynamic models
- system
- identification
- state space models
- Fluorescence-guided resection
- TECHNOLOGY
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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