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Family history of t...
Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA)
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- Hjort, Rebecka (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Unit Epidemiol, S-17177 Stockholm, Sweden.
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- Alfredsson, L (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden.
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- Andersson, T. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Unit Epidemiol, S-17177 Stockholm, Sweden.;Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden.
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Uppsala University,Institutionen för medicinska vetenskaper
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- Grill, V (författare)
- St. Olav’s University Hospital,Norwegian Univ Sci & Technol, NTNU Inst Canc Res & Mol Med, Trondheim, Norway.;Trondheim Reg & Univ Hosp, Dept Endocrinol, Trondheim, Norway.
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- Groop, L. (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmo, Malmo, Sweden.
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- Martinell, Mats, 1971- (författare)
- Uppsala universitet,Uppsala University,Allmänmedicin och preventivmedicin
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- Rasouli, B. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Unit Epidemiol, S-17177 Stockholm, Sweden.
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- Storm, P. (författare)
- Lund University,Lunds universitet,Glukostransport och proteintrafficking,Forskargrupper vid Lunds universitet,Glucose Transport and Protein Trafficking,Lund University Research Groups,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmo, Malmo, Sweden.
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- Tuomi, T. (författare)
- Helsinki University Central Hospital,Univ Helsinki, Div Endocrinol, Abdominal Ctr, Finnish Inst Mol Med, Helsinki, Finland.;Univ Helsinki, Res Program Diabet & Obes, Helsinki, Finland.;Helsinki Univ Hosp, Folkhalsan Res Ctr, Helsinki, Finland.
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- Carlsson, S. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Unit Epidemiol, S-17177 Stockholm, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Diabetes & Metabolism. - : Elsevier BV. - 1262-3636 .- 1878-1780. ; 43:6, s. 536-542
- Relaterad länk:
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http://dx.doi.org/10...
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https://helda.helsin...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: A family history of diabetes (FHD) is a strong predictor of diabetes risk, yet has rarely been investigated in latent autoimmune diabetes in adults (LADA). This study therefore investigated the risk of LADA and type 2 diabetes (T2D) in relation to FHD, taking into account the type of diabetes in relatives. Methods: Data from a population-based study were used, including incident cases of LADA [glutamic acid decarboxylase antibody (GADA)-positive, n = 378] and T2D (GADA-negative, n = 1199), and their matched controls (n = 1484). First-degree relatives with disease onset at age. <. 40 years and taking insulin treatment were classified as type 1 diabetes (T1D) or, if otherwise, as T2D. Odds ratios (ORs) were adjusted for age, gender, BMI, education and smoking. Cases were genotyped for high- and low-risk HLA genotypes. Results: Both FHD-T1D (OR: 5.8; 95% CI: 3.2-10.3) and FHD-T2D (OR: 1.9; 95% CI: 1.5-2.5) were associated with an increased risk of LADA, whereas the risk of T2D was associated with FHD-T2D (OR: 2.7; 95% CI: 2.2-3.3), but not FHD-T1D. In LADA patients, FHD-T1D vs FHD-T2D was associated with higher GADA but lower C-peptide levels, lower prevalence of low-risk HLA genotypes (5.0% vs 28.6%, respectively; P = 0.038) and a tendency for higher prevalence of high-risk genotypes (90.0% vs 69.1%, respectively; P = 0.0576). Conclusion: The risk of LADA is substantially increased with FHD-T1D but also, albeit significantly less so, with FHD-T2D. This supports the idea of LADA as a mix of both T1D and T2D, but suggests that the genes related to T1D have greater impact. LADA patients with FHD-T1D had more T1D-like features, emphasizing the heterogeneity of LADA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Autoimmune diabetes
- Case-control study
- Family history of diabetes
- Heredity
- Latent autoimmune diabetes in adults
- Type 2 diabetes
- Autoimmune diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Hjort, Rebecka
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Alfredsson, L
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Andersson, T.
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Carlsson, Per-Ol ...
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Grill, V
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Groop, L.
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Martinell, Mats, ...
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Rasouli, B.
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Storm, P.
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Tuomi, T.
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Carlsson, S.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Diabetes & Metab ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet
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Uppsala universitet