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Pharmacological Med...
Pharmacological Medical Treatment of Epilepsy in Patients with Dementia : A Systematic Review
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- Musaeus, Christian S. (författare)
- Copenhagen University Hospital
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- Nilsson, Christer (författare)
- Lund University,Lunds universitet,Translationell Neurologi,Forskargrupper vid Lunds universitet,Klinisk minnesforskning,Translational Neurology (TNY),Lund University Research Groups,Clinical Memory Research,Skåne University Hospital
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- Cooper, Chris (författare)
- University College London
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- Kramberger, Milica G. (författare)
- University Medical Centre Ljubljana
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- Verdelho, Ana (författare)
- Portuguese National Programme for Respiratory Diseases (PNDR)
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- Stefanova, Elka (författare)
- University of Belgrade
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- Religa, Dorota (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Waldemar, Gunhild (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Frederiksen, Kristian S. (författare)
- Copenhagen University Hospital
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(creator_code:org_t)
- Bentham Science Publishers Ltd. 2021
- 2021
- Engelska 6 s.
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Ingår i: Current Alzheimer Research. - : Bentham Science Publishers Ltd.. - 1567-2050 .- 1875-5828. ; 18:9, s. 689-694
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Patients with dementia have an increased risk of developing epilepsy, es-pecially in patients with vascular dementia and Alzheimer’s disease. In selecting the optimal an-ti-epileptic drug (AED), the possible side effects such as drowsiness and worsening of cognitive function should be taken into consideration, together with co-morbidities and type of epilepsy. Objective: The current systematic review investigates the efficacy, tolerability, and changes in cognitive function after administration of AED in patients with dementia and epilepsy. Methods: We searched six databases, including MEDLINE and CENTRAL, checked reference lists, contacted experts, and searched Google Scholar to identify studies reporting randomized trials. Studies identified were independently screened, data extracted, and quality appraised by two researchers. A narrative synthesis was used to report findings. Results: We included one study with 95 patients with Alzheimer’s disease randomized to either lev-etiracetam, lamotrigine, or phenobarbital. No significant differences were found for efficacy, but patients receiving levetiracetam showed an improvement in mini-mental state examination scores and had fewer adverse events. Conclusion: High-quality evidence in the form of randomized controlled trials to guide clinicians in choosing an AED in patients with dementia and concomitant epilepsy remains scarce. However, levetiracetam has previously been shown to possibly improve cognition in patients with both mild cognitive impairment and Alzheimer’s disease, is better tolerated in the elderly population, and has no clinically relevant interaction with either cholinesterase inhibitors or NMDA receptor antagon-ists. Registration No: The protocol was registered in the PROSPERO database (ID: CRD42020176252).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer’s disease
- Anti-epileptic medication
- Dementia
- Epilepsy
- Levetiracetam
- Older adults
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
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