Sökning: onr:"swepub:oai:lup.lub.lu.se:446a3349-5fb8-4cfd-beb3-de7786302b82" > Genome Wide Meta-an...
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000 | 04737naa a2200637 4500 | |
001 | oai:lup.lub.lu.se:446a3349-5fb8-4cfd-beb3-de7786302b82 | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/49079232 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.10048542 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Tönjes, Anke4 aut |
245 | 1 0 | a Genome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin. |
264 | c 2014-12-18 | |
264 | 1 | b Public Library of Science (PLoS),c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Chemerin is an adipokine proposed to link obesity and chronic inflammation of adipose tissue. Genetic factors determining chemerin release from adipose tissue are yet unknown. We conducted a meta-analysis of genome-wide association studies (GWAS) for serum chemerin in three independent cohorts from Europe: Sorbs and KORA from Germany and PPP-Botnia from Finland (total N = 2,791). In addition, we measured mRNA expression of genes within the associated loci in peripheral mononuclear cells by micro-arrays, and within adipose tissue by quantitative RT-PCR and performed mRNA expression quantitative trait and expression-chemerin association studies to functionally substantiate our loci. Heritability estimate of circulating chemerin levels was 16.2% in the Sorbs cohort. Thirty single nucleotide polymorphisms (SNPs) at chromosome 7 within the retinoic acid receptor responder 2 (RARRES2)/Leucine Rich Repeat Containing (LRRC61) locus reached genome-wide significance (p<5.0×10-8) in the meta-analysis (the strongest evidence for association at rs7806429 with p = 7.8×10-14, beta = -0.067, explained variance 2.0%). All other SNPs within the cluster were in linkage disequilibrium with rs7806429 (minimum r2 = 0.43 in the Sorbs cohort). The results of the subgroup analyses of males and females were consistent with the results found in the total cohort. No significant SNP-sex interaction was observed. rs7806429 was associated with mRNA expression of RARRES2 in visceral adipose tissue in women (p<0.05 after adjusting for age and body mass index). In conclusion, the present meta-GWAS combined with mRNA expression studies highlights the role of genetic variation in the RARRES2 locus in the regulation of circulating chemerin concentrations. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Scholz, Markus4 aut |
700 | 1 | a Breitfeld, Jana4 aut |
700 | 1 | a Marzi, Carola4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Gross, Arnd4 aut |
700 | 1 | a Ladenvall, Claes4 aut |
700 | 1 | a Schleinitz, Dorit4 aut |
700 | 1 | a Krause, Kerstin4 aut |
700 | 1 | a Kirsten, Holger4 aut |
700 | 1 | a Laurila, Esau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-ela |
700 | 1 | a Kriebel, Jennifer4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Rathmann, Wolfgang4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Beutner, Frank4 aut |
700 | 1 | a Kratzsch, Jürgen4 aut |
700 | 1 | a Thiery, Joachim4 aut |
700 | 1 | a Fasshauer, Mathias4 aut |
700 | 1 | a Klöting, Nora4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Blüher, Matthias4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Kovacs, Peter4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t PLoS Geneticsd : Public Library of Science (PLoS)g 10:12q 10:12x 1553-7404 |
856 | 4 | u https://portal.research.lu.se/files/2385121/7851915x primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25521368?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1371/journal.pgen.1004854x freey FULLTEXT |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004854&type=printable |
856 | 4 8 | u https://lup.lub.lu.se/record/4907923 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1004854 |
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