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Human Lipoproteins ...
Human Lipoproteins at Model Cell Membranes : Effect of Lipoprotein Class on Lipid Exchange
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- Browning, Kathryn L. (författare)
- Uppsala universitet,Uppsala University,Institutionen för farmaci
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- Lind, T. K. (författare)
- Malmö University,Malmo Univ, Dept Biomed Sci & Biofilms, Malmo, Sweden.
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- Maric, S. (författare)
- Malmö University,Malmo Univ, Dept Biomed Sci & Biofilms, Malmo, Sweden.
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- Malekkhaiat Häffner, Sara (författare)
- Uppsala universitet,Uppsala University,Institutionen för farmaci
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- Fredrikson, G. N. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Lund Univ, Dept Clin Sci, Malmo, Sweden.
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- Bengtsson, E. (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine,Lund Univ, Dept Clin Sci, Malmo, Sweden.
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- Malmsten, Martin (författare)
- Uppsala universitet,Uppsala University,University of Copenhagen,Institutionen för farmaci,Univ Copenhagen, Dept Pharm, Copenhagen, Denmark.,Malmo Univ, Dept Biomed Sci & Biofilms, Malmo, Sweden.
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- Cárdenas, M. (författare)
- Malmö University
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(creator_code:org_t)
- 2017-08-07
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- High and low density lipoproteins (HDL and LDL) are thought to play vital roles in the onset and development of atherosclerosis; the biggest killer in the western world. Key issues of initial lipoprotein (LP) interactions at cellular membranes need to be addressed including LP deposition and lipid exchange. Here we present a protocol for monitoring the in situ kinetics of lipoprotein deposition and lipid exchange/removal at model cellular membranes using the non-invasive, surface sensitive methods of neutron reflection and quartz crystal microbalance with dissipation. For neutron reflection, lipid exchange and lipid removal can be distinguished thanks to the combined use of hydrogenated and tail-deuterated lipids. Both HDL and LDL remove lipids from the bilayer and deposit hydrogenated material into the lipid bilayer, however, the extent of removal and exchange depends on LP type. These results support the notion of HDL acting as the 'good' cholesterol, removing lipid material from lipid-loaded cells, whereas LDL acts as the 'bad' cholesterol, depositing lipid material into the vascular wall.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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