Sökning: onr:"swepub:oai:lup.lub.lu.se:47964497-d34a-49c3-bc1e-c756153379ce" >
Quantifying the uti...
Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children
-
- Ng, Kenney (författare)
- IBM Research Cambridge
-
- Anand, Vibha (författare)
- IBM Research Cambridge
-
- Stavropoulos, Harry (författare)
- IBM Research
-
visa fler...
-
- Veijola, Riitta (författare)
- University of Oulu
-
- Toppari, Jorma (författare)
- Turku University Hospital,University of Turku
-
- Maziarz, Marlena (författare)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
-
- Lundgren, Markus (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad
-
- Waugh, Kathy (författare)
- University of Colorado
-
- Frohnert, Brigitte I. (författare)
- University of Colorado
-
- Martin, Frank (författare)
- Juvenile Diabetes Research Foundation
-
- Lou, Olivia (författare)
- Juvenile Diabetes Research Foundation
-
- Hagopian, William (författare)
- Pacific Northwest Research Institute
-
- Achenbach, Peter (författare)
- Helmholtz Zentrum München
-
visa färre...
-
(creator_code:org_t)
-
- 2022-10-05
- 2023
- Engelska 12 s.
-
Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 66:1, s. 93-104
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims/hypothesis: The aim of this study was to explore the utility of islet autoantibody (IAb) levels for the prediction of type 1 diabetes in autoantibody-positive children. Methods: Prospective cohort studies in Finland, Germany, Sweden and the USA followed 24,662 children at increased genetic or familial risk of developing islet autoimmunity and diabetes. For the 1403 who developed IAbs (523 of whom developed diabetes), levels of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA) and insulinoma-associated antigen-2 (IA-2A) were harmonised for analysis. Diabetes prediction models using multivariate logistic regression with inverse probability censored weighting (IPCW) were trained using 10-fold cross-validation. Discriminative power for disease was estimated using the IPCW concordance index (C index) with 95% CI estimated via bootstrap. Results: A baseline model with covariates for data source, sex, diabetes family history, HLA risk group and age at seroconversion with a 10-year follow-up period yielded a C index of 0.61 (95% CI 0.58, 0.63). The performance improved after adding the IAb positivity status for IAA, GADA and IA-2A at seroconversion: C index 0.72 (95% CI 0.71, 0.74). Using the IAb levels instead of positivity indicators resulted in even better performance: C index 0.76 (95% CI 0.74, 0.77). The predictive power was maintained when using the IAb levels alone: C index 0.76 (95% CI 0.75, 0.76). The prediction was better for shorter follow-up periods, with a C index of 0.82 (95% CI 0.81, 0.83) at 2 years, and remained reasonable for longer follow-up periods, with a C index of 0.76 (95% CI 0.75, 0.76) at 11 years. Inclusion of the results of a third IAb test added to the predictive power, and a suitable interval between seroconversion and the third test was approximately 1.5 years, with a C index of 0.78 (95% CI 0.77, 0.78) at 10 years follow-up. Conclusions/interpretation: Consideration of quantitative patterns of IAb levels improved the predictive power for type 1 diabetes in IAb-positive children beyond qualitative IAb positivity status. Graphical abstract: [Figure not available: see fulltext.]
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Islet autoantibody levels
- Machine learning
- Risk prediction models
- Type 1 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ng, Kenney
-
Anand, Vibha
-
Stavropoulos, Ha ...
-
Veijola, Riitta
-
Toppari, Jorma
-
Maziarz, Marlena
-
visa fler...
-
Lundgren, Markus
-
Waugh, Kathy
-
Frohnert, Brigit ...
-
Martin, Frank
-
Lou, Olivia
-
Hagopian, Willia ...
-
Achenbach, Peter
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetologia
- Av lärosätet
-
Lunds universitet