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IL-2 overcomes the ...
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Anderson, PerLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
(författare)
IL-2 overcomes the unresponsiveness but fails to reverse the regulatory function of antigen-induced T regulatory cells
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:47c60f12-cff1-4ed9-9026-124810143574
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https://lup.lub.lu.se/record/258392URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Intranasal administration of peptide Acl-9[4Y], based on the N-terminal epitope of myelin basic protein, can induce CD4(+) T cell tolerance, and suppress experimental autoimmune encephalomyelitis induction. The peptide-induced regulatory T (PI-T-Reg) cells failed to produce IL-2, but expressed IL-10 in response to Ag and could suppress naive T cell responses in vitro. Analysis of Jak-STAT signaling pathways revealed that the activation of Jak1, STAT3, and STAT5 were induced in tolerant T cells after Ag stimulation in vivo. In addition, the expression of suppressor of cytokine signaling 3 was induced in tolerant T cells, suggesting that cytokines regulate the tolerant state of the PI-T-Reg cells. Stimulation of PI-T-Reg cells in vitro with IL-10 induced Jak1 and STAT3 activation, but not STAT5, suggesting that IL-10 is important, but not the only cytokine involved in the development of T cell tolerance. Although IL-2 expression was deficient, stimulation with IL-2 in vitro induced Jak1 and STAT5 activation in PI-T-Reg cells, restored their proliferative response to antigenic stimulation, and abrogated PI-T-Reg-mediated suppression in vitro. However, the addition of IL-2 could not suppress IL-10 expression, and the IL-2 gene remained inactive. After withdrawal of IL-2, the PI-T-Reg cells regained their nonproliferative state and suppressive ability. These results underline the ability of the immune system to maintain tolerance to autoantigens, but at the same time having the ability to overcome the suppressive phenotype of tolerant T cells by cytokines, such as IL-2, during the protective immune response to infection.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sundstedt, A
(författare)
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Yazici, Z
(författare)
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Minaee, S
(författare)
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Woolf, R
(författare)
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Nicolson, K
(författare)
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Whitley, N
(författare)
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Li, LiLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)wbl-lli
(författare)
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Li, Su-LingLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)wbl-sll
(författare)
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Wraith, DC
(författare)
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Wang, PingLund University,Lunds universitet,Strömningsteknik,Institutionen för energivetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Fluid Mechanics,Department of Energy Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)vok-pwa
(författare)
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ImmunologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Immunology174:1, s. 310-3191550-6606
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Till lärosätets databas
- Av författaren/redakt...
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Anderson, Per
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Sundstedt, A
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Yazici, Z
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Minaee, S
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Woolf, R
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Nicolson, K
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visa fler...
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Whitley, N
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Li, Li
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Li, Su-Ling
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Wraith, DC
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Wang, Ping
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visa färre...
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Lunds universitet