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Analyses of registr...
Analyses of registry data of patients with anti-GBM and antineutrophil cytoplasmatic antibody-associated (ANCA) vasculitis treated with or without therapeutic apheresis
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- Mörtzell Henriksson, Monica (författare)
- Umeå universitet,Umeå University,Umea Univ, Sweden,Avdelningen för medicin
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- Weiner, Maria (författare)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Department of Nephrology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
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- Sperker, Wolfgang (författare)
- Umeå universitet,Umeå University,Umea Univ, Sweden,Avdelningen för medicin
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- Berlin, G. (författare)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin,Department of Clinical Immunology and Transfusion Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
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- Segelmark, M. (författare)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden,Department of Clinical Sciences, Lund University, Lund, Sweden
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- Javier Martinez, A. (författare)
- Uppsala University,Uppsala Univ, Sweden,Vilnius Univ, Lithuania,Vilnius University, Vilnius, Lithuania,Uppsala University, Uppsala, Sweden
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- Audzijoniene, J. (författare)
- Vilnius University
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- Griskevicius, A. (författare)
- Vilnius University, Vilnius, Lithuania,Vilnius Univ, Lithuania
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- Newman, E. (författare)
- Concord Repatriation General Hospital,Concord Hosp, Australia,Concord Hospital, Sydney, Australia
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- Blaha, M. (författare)
- University of Hradec Králové,Kralove Univ, Czech Republic,Kralove University, Kralove, Czech Republic
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- Vrielink, H. (författare)
- Sanquin Blood Supply,, Amsterdam, Sanquin, Netherlands
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- Witt, V. (författare)
- St. Anna Children's Hospital,St Anna Childrens Hosp, Austria,St Anna Kinderspital, Vienna, Austria
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- Stegmayr, Bernd, 1949- (författare)
- Umeå universitet,Umeå University,Umea Univ, Sweden,Avdelningen för medicin
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Transfusion and Apheresis Science. - : Elsevier BV. - 1473-0502 .- 1878-1683. ; 60:6
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Therapeutic apheresis (TA) as a treatment for antibody-associated vasculitis (AAV) was questioned by the PEXIVAS although the MEPEX study favored TA. The aim of this study was to evaluate the efficacy of TA to improve renal function in patients consecutively included in the WAA-apheresis registry versus patients not treated with TA. Materials and methods: Included were 192 patients that suffered from anti-glomerular basement membrane disease (anti-GBM, n = 28) and antineutrophil cytoplasmic antibody-associated vasculitis of MPO or PR3 origin. Of these 119 had performed TA and the other 73 had not performed TA for theses diagnoses (CTRL). Results: Elderly had an increased risk to die within 12 months (p = 0.002). All 28 anti-GBM had renal involvement, 21 dialysis dependent. At 3 month nine (36 %) did not need dialysis. Baseline data regarding renal function of AAV patients, subtype MPO and PR3, were worse in the TA groups than in CTRL. Recovery out of dialysis was better for the PR3-TA group compared with 1) the controls of MEPEX (RR 0.59, CI 0.43−0.80) and 2) the MPO-TA patients (RR 0.28, CI 0.12−0.68). The MPO-TA recovered similarly as the MEPEX-CTRL. Renal function improved most for TA-patients from baseline during the first 3 months (MPO-TA and PR3-TA) and stabilized thereafter and less for MPO-CTRL and PR3-CTRL. Conclusion: PR3-TA patients seem to have best chances to get out of dialysis. PR3-TA and MPO-TA improved residual renal function better than CTRL. The present study recommends reconsiderations to use TA for AAV especially those with PR3-vasculitis with severe renal vasculitis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Anti-GBM
- Antibodies
- MPO
- PR-3
- Renal impairment
- Therapeutic apheresis
- Vasculitis
- Therapeutic apheresis; Antibodies; Vasculitis; Renal impairment; PR-3; MPO; Anti-GBM
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Mörtzell Henriks ...
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Weiner, Maria
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Sperker, Wolfgan ...
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Berlin, G.
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Segelmark, M.
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Javier Martinez, ...
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visa fler...
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Audzijoniene, J.
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Griskevicius, A.
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Newman, E.
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Blaha, M.
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Vrielink, H.
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Witt, V.
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Stegmayr, Bernd, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Transfusion and ...
- Av lärosätet
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Lunds universitet
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Linköpings universitet
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Umeå universitet