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Risk assessment for...
Risk assessment for endometrial cancer in women with abnormal vaginal bleeding : Results from the prospective IETA-1 cohort study
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- Verbakel, Jan Yvan (författare)
- Catholic University of Leuven,University of Oxford
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- Heremans, Ruben (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Wynants, Laure (författare)
- Catholic University of Leuven,Maastricht University
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- Epstein, Elisabeth (författare)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- De Cock, Bavo (författare)
- Catholic University of Leuven
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- Pascual, Maria Angela (författare)
- University Hospital Dexeus
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- Leone, Francesco Paolo Giuseppe (författare)
- Luigi Sacco University Hospital
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- Sladkevicius, Povilas (författare)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Alcazar, Juan Luis (författare)
- University of Navarra
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- Van Pachterbeke, Catherine (författare)
- University Hospital Brugmann
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- Jokubkiene, Ligita (författare)
- Skåne University Hospital
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- Fruscio, Robert (författare)
- University of Milano-Bicocca
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- Bourne, Tom (författare)
- Catholic University of Leuven,Queen Charlotte's and Chelsea Hospital
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- Van Calster, Ben (författare)
- Leiden University,Catholic University of Leuven
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- Timmerman, Dirk (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Van den Bosch, Thierry (författare)
- Catholic University of Leuven,University Hospitals Leuven
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(creator_code:org_t)
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- 2022-02-07
- 2022
- Engelska.
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Ingår i: International Journal of Gynecology and Obstetrics. - : Wiley. - 0020-7292 .- 1879-3479. ; 159:1, s. 103-110
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To investigate the association between personal history, anthropometric features and lifestyle characteristics and endometrial malignancy in women with abnormal vaginal bleeding. Methods: Prospective observational cohort assessed by descriptive and multivariable logistic regression analyses. Three features—age, body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters), and nulliparity—were defined a priori for baseline risk assessment of endometrial malignancy. The following variables were tested for added value: intrauterine contraceptive device, bleeding pattern, age at menopause, coexisting diabetes/hypertension, physical exercise, fat distribution, bra size, waist circumference, smoking/drinking habits, family history, use of hormonal/anticoagulant therapy, and sonographic endometrial thickness. We calculated adjusted odds ratio, optimism-corrected area under the receiver operating characteristic curve (AUC), R2, and Akaike's information criterion. Results: Of 2417 women, 155 (6%) had endometrial malignancy or endometrial intraepithelial neoplasia. In women with endometrial cancer median age was 67 years (interquartile range [IQR] 56–75 years), median parity was 2 (IQR 0–10), and median BMI was 28 (IQR 25–32). Age, BMI, and parity produced an AUC of 0.82. Other variables marginally affected the AUC, adding endometrial thickness substantially increased the AUC in postmenopausal women. Conclusion: Age, parity, and BMI help in the assessment of endometrial cancer risk in women with abnormal uterine bleeding. Other patient information adds little, whereas sonographic endometrial thickness substantially improves assessment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- endometrial neoplasms
- endometrium
- uterine hemorrhage
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Verbakel, Jan Yv ...
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Heremans, Ruben
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Wynants, Laure
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Epstein, Elisabe ...
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De Cock, Bavo
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Pascual, Maria A ...
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visa fler...
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Leone, Francesco ...
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Sladkevicius, Po ...
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Alcazar, Juan Lu ...
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Van Pachterbeke, ...
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Jokubkiene, Ligi ...
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Fruscio, Robert
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Bourne, Tom
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Van Calster, Ben
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Timmerman, Dirk
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Van den Bosch, T ...
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Lunds universitet
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Karolinska Institutet