Sökning: onr:"swepub:oai:lup.lub.lu.se:48c852f4-7452-4837-a0c2-e28a87eaf0be" > Increase in insulin...
Fältnamn | Indikatorer | Metadata |
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000 | 03787naa a2200397 4500 | |
001 | oai:lup.lub.lu.se:48c852f4-7452-4837-a0c2-e28a87eaf0be | |
003 | SwePub | |
008 | 160401s1994 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11085282 URI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Chen, Y4 aut |
245 | 1 0 | a Increase in insulin-like growth factor I in hypertrophying smooth muscle |
264 | 1 | c 1994 |
520 | a The present study focuses on the role of the insulin-like growth factor (IGF) system in the development of smooth muscle hypertrophy. Hypertrophy was initiated by partial ligation of portal vein or urethra in female Sprague-Dawley rats weighing approximately 220 g. Levels of mRNA were analyzed by solution hybridization. Seven days after ligation, the wet weight of the portal vein was increased about threefold and the concentration of IGF-I mRNA was increased fourfold. The bladder wet weight was increased twofold 3 days after ligation and fourfold 10 days after ligation. IGF-I mRNA in the bladder was elevated 3-fold after 3 days and 2.5-fold after 10 days, whereas IGF binding protein 2 mRNA was increased approximately 2-fold after 3 days and 5-fold after 10 days. IGF-I receptor mRNA in the hypertrophying bladder remained unchanged. Increased levels of IGF-I were demonstrated with immunohistochemistry in both hypertrophying portal vein and urinary bladder. The results show a specific increase in IGF-I mRNA as well as an increased IGF-I immunoreactivity during hypertrophy of smooth muscle, which suggests that the local IGF-system may play a role in smooth muscle hypertrophy. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
700 | 1 | a Bornfeldt, K E4 aut |
700 | 1 | a Arner, Andersu Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups4 aut0 (Swepub:lu)an8151ar |
700 | 1 | a Jennische, E4 aut |
700 | 1 | a Malmqvist, Ulfu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mphy-uma |
700 | 1 | a Uvelius, Bengtu Lund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups4 aut0 (Swepub:lu)uro-buv |
700 | 1 | a Arnqvist, H J4 aut |
710 | 2 | a Kärlfysiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t American Journal of Physiology - Endocrinology and Metabolismg 266:2 Pt 1, s. 224-229q 266:2 Pt 1<224-229x 1522-1555 |
856 | 4 | u http://ajpendo.physiology.org/cgi/reprint/266/2/E224y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1108528 |
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