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Sökning: onr:"swepub:oai:lup.lub.lu.se:4a57b413-a736-4437-a5cc-e63bb54392ba" > Pharmacokinetic mod...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003744naa a2200433 4500
001oai:lup.lub.lu.se:4a57b413-a736-4437-a5cc-e63bb54392ba
003SwePub
008160401s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/42918652 URI
0247 a https://doi.org/10.1038/ki.2013.5172 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Colom, Helena4 aut
2451 0a Pharmacokinetic modeling of enterohepatic circulation of mycophenolic acid in renal transplant recipients.
264 1b Elsevier BV,c 2014
520 a Several factors contribute to mycophenolic acid (MPA) between-patient variability. Here we characterize the metabolic pathways of MPA and quantify the effect of combining genetic polymorphism of multidrug-resistant-associated protein-2, demographics, biochemical covariates, co-medication (cyclosporine (CsA) vs. macrolides), and renal function on MPA, 7-O-MPA-glucuronide (MPAG), and acyl-glucuronide (AcMPAG) disposition, in renal transplant recipients, after mycophenolate mofetil. Complete pharmacokinetic profiles from 56 patients (five occasions) were analyzed. Enterohepatic circulation was modeled by transport of MPAG to the absorption site. This transport significantly decreased with increasing CsA trough concentrations (CtroughCsA). MPAG and AcMPAG plasma clearances significantly decreased with renal function. No significant influence of multidrug-resistant-associated protein-2 C24T single-nucleotide polymorphism was found. The model adequately predicted the increase in MPAG/AcMPAG exposures in CsA and macrolide patients with decreased renal function. This resulted in higher MPA exposures in macrolide patients versus CsA patients, and increased MPA exposures with renal function from 25 to 10 ml/min, in macrolide patients, owing to enhanced MPAG enterohepatic circulation. Lower-percentage enterohepatic circulation occurred with higher CtroughCsA and renal function values. The lack of MPA protein-binding modeling did not permit evaluation of the impact of renal function and CtroughCsA on MPA exposures in CsA patients. Thus, dose tailoring of covariates is recommended for target MPA exposure.Kidney International advance online publication, 8 January 2014; doi:10.1038/ki.2013.517.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
7001 a Lloberas, Núria4 aut
7001 a Andreu, Franc4 aut
7001 a Caldés, Ana4 aut
7001 a Torras, Joan4 aut
7001 a Oppenheimer, Federico4 aut
7001 a Sanchez-Plumed, Jaime4 aut
7001 a Gentil, Miguel A4 aut
7001 a Kuypers, Dirk R4 aut
7001 a Brunet, Mercè4 aut
7001 a Ekberg, Henriku Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hek
7001 a Grinyó, Josep M4 aut
7102 a Enheten för forskning kring njurfunktion och njursjukdomb Kirurgi4 org
7730 t Kidney Internationald : Elsevier BVg 85:6, s. 1434-1443q 85:6<1434-1443x 1523-1755x 0085-2538
8564 u http://www.ncbi.nlm.nih.gov/pubmed/24402086?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1038/ki.2013.517y FULLTEXT
8564 u http://www.kidney-international.org/article/S0085253815563680/pdf
8564 8u https://lup.lub.lu.se/record/4291865
8564 8u https://doi.org/10.1038/ki.2013.517

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