Sökning: onr:"swepub:oai:lup.lub.lu.se:4a57b413-a736-4437-a5cc-e63bb54392ba" > Pharmacokinetic mod...
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000 | 03744naa a2200433 4500 | |
001 | oai:lup.lub.lu.se:4a57b413-a736-4437-a5cc-e63bb54392ba | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/42918652 URI |
024 | 7 | a https://doi.org/10.1038/ki.2013.5172 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Colom, Helena4 aut |
245 | 1 0 | a Pharmacokinetic modeling of enterohepatic circulation of mycophenolic acid in renal transplant recipients. |
264 | 1 | b Elsevier BV,c 2014 |
520 | a Several factors contribute to mycophenolic acid (MPA) between-patient variability. Here we characterize the metabolic pathways of MPA and quantify the effect of combining genetic polymorphism of multidrug-resistant-associated protein-2, demographics, biochemical covariates, co-medication (cyclosporine (CsA) vs. macrolides), and renal function on MPA, 7-O-MPA-glucuronide (MPAG), and acyl-glucuronide (AcMPAG) disposition, in renal transplant recipients, after mycophenolate mofetil. Complete pharmacokinetic profiles from 56 patients (five occasions) were analyzed. Enterohepatic circulation was modeled by transport of MPAG to the absorption site. This transport significantly decreased with increasing CsA trough concentrations (CtroughCsA). MPAG and AcMPAG plasma clearances significantly decreased with renal function. No significant influence of multidrug-resistant-associated protein-2 C24T single-nucleotide polymorphism was found. The model adequately predicted the increase in MPAG/AcMPAG exposures in CsA and macrolide patients with decreased renal function. This resulted in higher MPA exposures in macrolide patients versus CsA patients, and increased MPA exposures with renal function from 25 to 10 ml/min, in macrolide patients, owing to enhanced MPAG enterohepatic circulation. Lower-percentage enterohepatic circulation occurred with higher CtroughCsA and renal function values. The lack of MPA protein-binding modeling did not permit evaluation of the impact of renal function and CtroughCsA on MPA exposures in CsA patients. Thus, dose tailoring of covariates is recommended for target MPA exposure.Kidney International advance online publication, 8 January 2014; doi:10.1038/ki.2013.517. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
700 | 1 | a Lloberas, Núria4 aut |
700 | 1 | a Andreu, Franc4 aut |
700 | 1 | a Caldés, Ana4 aut |
700 | 1 | a Torras, Joan4 aut |
700 | 1 | a Oppenheimer, Federico4 aut |
700 | 1 | a Sanchez-Plumed, Jaime4 aut |
700 | 1 | a Gentil, Miguel A4 aut |
700 | 1 | a Kuypers, Dirk R4 aut |
700 | 1 | a Brunet, Mercè4 aut |
700 | 1 | a Ekberg, Henriku Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hek |
700 | 1 | a Grinyó, Josep M4 aut |
710 | 2 | a Enheten för forskning kring njurfunktion och njursjukdomb Kirurgi4 org |
773 | 0 | t Kidney Internationald : Elsevier BVg 85:6, s. 1434-1443q 85:6<1434-1443x 1523-1755x 0085-2538 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24402086?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1038/ki.2013.517y FULLTEXT |
856 | 4 | u http://www.kidney-international.org/article/S0085253815563680/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/4291865 |
856 | 4 8 | u https://doi.org/10.1038/ki.2013.517 |
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