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Relationship between Blood Pressure and Incident Cardiovascular Disease : Linear and Nonlinear Mendelian Randomization Analyses
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- Malik, Rainer (författare)
- University Hospital Munich
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- Georgakis, Marios K. (författare)
- University Hospital Munich
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- Vujkovic, Marijana (författare)
- Veterans Health Administration,Cochin Hospital
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- Damrauer, Scott M. (författare)
- Cochin Hospital,Veterans Health Administration
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- Elliott, Paul (författare)
- Health Data Research UK,Imperial College London,MRC Human Nutrition Research,Imperial College Healthcare NHS Trust,British Heart Foundation
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- Karhunen, Ville (författare)
- Imperial College London
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- Giontella, Alice (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University of Verona
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- Fava, Cristiano (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University of Verona
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- Hellwege, Jacklyn N. (författare)
- Vanderbilt University
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- Shuey, Megan M. (författare)
- Vanderbilt University
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- Edwards, Todd L. (författare)
- Vanderbilt University
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- Rogne, Tormod (författare)
- Yale University,Norwegian University of Science and Technology,St. Olav’s University Hospital
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- Åsvold, Bjørn O. (författare)
- Norwegian University of Science and Technology,St. Olav’s University Hospital
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- Brumpton, Ben M. (författare)
- St. Olav’s University Hospital
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- Burgess, Stephen (författare)
- University of Cambridge
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- Dichgans, Martin (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich
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- Gill, Dipender (författare)
- British Heart Foundation,Novo Nordisk Research Centre Oxford,St George's, University of London,Imperial College London,St George's Hospital, London
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(creator_code:org_t)
- 2021
- 2021
- Engelska 10 s.
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Ingår i: Hypertension. - 0194-911X. ; 77:6, s. 2004-2013
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Observational studies exploring whether there is a nonlinear effect of blood pressure on cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be overcome by leveraging randomly allocated genetic variants in nonlinear Mendelian randomization analyses. Based on their association with blood pressure traits in a genome-wide association study of 299 024 European ancestry individuals, we selected 253 genetic variants to proxy the effect of modifying systolic and diastolic blood pressure. Considering the outcomes of incident coronary artery disease, stroke and the combined outcome of CVD, linear and nonlinear Mendelian randomization analyses were performed on 255 714 European ancestry participants without a history of CVD or antihypertensive medication use. There was no evidence favoring nonlinear relationships of genetically proxied systolic and diastolic blood pressure with the cardiovascular outcomes over linear relationships. For every 10-mm Hg increase in genetically proxied systolic blood pressure, risk of incident CVD increased by 49% (hazard ratio, 1.49 [95% CI, 1.38-1.61]), with similar estimates obtained for coronary artery disease (hazard ratio, 1.50 [95% CI, 1.38-1.63]) and stroke (hazard ratio, 1.44 [95% CI, 1.22-1.70]). Genetically proxied blood pressure had a similar relationship with CVD in men and women. These findings provide evidence to support that even for individuals who do not have elevated blood pressure, public health interventions achieving persistent blood pressure reduction will be of considerable benefit in the primary prevention of CVD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- blood pressure
- coronary artery disease
- hypertension
- primary prevention
- stroke
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Malik, Rainer
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Georgakis, Mario ...
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Vujkovic, Marija ...
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Damrauer, Scott ...
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Elliott, Paul
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Karhunen, Ville
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visa fler...
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Giontella, Alice
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Fava, Cristiano
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Hellwege, Jackly ...
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Shuey, Megan M.
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Edwards, Todd L.
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Rogne, Tormod
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Åsvold, Bjørn O.
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Brumpton, Ben M.
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Burgess, Stephen
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Dichgans, Martin
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Gill, Dipender
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Hypertension
- Av lärosätet
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Lunds universitet