Sökning: onr:"swepub:oai:lup.lub.lu.se:4b3a8308-961c-4ff1-97d4-b0ccf1636b9c" > Polymorphisms in fa...
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000 | 10103naa a2200913 4500 | |
001 | oai:lup.lub.lu.se:4b3a8308-961c-4ff1-97d4-b0ccf1636b9c | |
003 | SwePub | |
008 | 160401s2010 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-31571 | |
024 | 7 | a https://lup.lub.lu.se/record/15896842 URI |
024 | 7 | a https://doi.org/10.1093/carcin/bgp3252 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-315712 URI |
040 | a (SwePub)lud (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Hoeft, Birgitu German Cancer Research Center, Heidelberg, Germany4 aut |
245 | 1 0 | a Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk |
264 | c 2009-12-30 | |
264 | 1 | b Oxford University Press (OUP),c 2010 |
520 | a Colorectal cancer (CRC) is the third most common malignant tumor and the fourth leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in-depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three hundred and ninety two single-nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of > 5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were associated with higher risk for CRC, whereas prostaglandin E receptor 2 (PTGER2) was associated with lower CRC risk. A significant inverse association (P < 0.006) was found for PTGER2 GGG haplotype, whereas HPGD AGGAG and PLA2G3 CT haplotypes were significantly (P < 0.001 and P = 0.003, respectively) associated with higher risk of CRC. Based on these data, we present for the first time the association of HPGD variants with CRC risk. Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Linseisen, Jakobu German Cancer Research Center, Heidelberg, Germany4 aut |
700 | 1 | a Beckmann, Larsu German Cancer Research Center, Heidelberg, Germany4 aut |
700 | 1 | a Mueller-Decker, Karinu German Cancer Research Center, Heidelberg, Germany4 aut |
700 | 1 | a Canzian, Federicou German Cancer Research Center, Heidelberg, Germany4 aut |
700 | 1 | a Huesing, Anikau German Cancer Research Center, Heidelberg, Germany4 aut |
700 | 1 | a Kaaks, Rudolfu German Cancer Research Center, Heidelberg, Germany4 aut |
700 | 1 | a Vogel, Ullau National Food Institute, Technical University of Denmark, Soborg, Denmark,National Research Centre for the Working Environment, Copenhagen, Denmark4 aut |
700 | 1 | a Jakobsen, Marianne U.u Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark4 aut |
700 | 1 | a Overvad, Kimu Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark4 aut |
700 | 1 | a Hansen, Rikke D.u Danish Cancer Society, Copenhagen, Denmark4 aut |
700 | 1 | a Knueppel, Svenu Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany4 aut |
700 | 1 | a Boeing, Heineru Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany4 aut |
700 | 1 | a Trichopoulou, Antoniau Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece,Hellenic Health Foundation, Greece4 aut |
700 | 1 | a Koumantaki, Yvoniu Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece4 aut |
700 | 1 | a Trichopoulos, Dimitriosu Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA4 aut |
700 | 1 | a Berrino, Francou Etiological Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy4 aut |
700 | 1 | a Palli, Domenicou Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy4 aut |
700 | 1 | a Panico, Salvatoreu Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy4 aut |
700 | 1 | a Tumino, Rosariou Cancer Registry and Histopathology Unit, Department of Oncology , “Civile - M.P.Arezzo” Hospital, Ragusa, Italy4 aut |
700 | 1 | a Bueno-de-Mesquita, H. B.u National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands4 aut |
700 | 1 | a van Duijnhoven, Franzel J. B.u National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands4 aut |
700 | 1 | a van Gils, Carla H.u Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands4 aut |
700 | 1 | a Peeters, Petra H.u Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK4 aut |
700 | 1 | a Dumeaux, Vanessau Institute of Community Medicine, University of Tromsø, Norway4 aut |
700 | 1 | a Lund, Eilivu Institute of Community Medicine, University of Tromsø, Norway4 aut |
700 | 1 | a Huerta Castano, Jose M.u CIBER Epidemiología y Salud Pública, CIBERESP, Spain,Council of Health and Consumer Affairs, Murcia, Spain4 aut |
700 | 1 | a Munoz, Xavieru Research Laboratory and Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain4 aut |
700 | 1 | a Rodriguez, Laudinau Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain4 aut |
700 | 1 | a Barricarte, Aureliou CIBER Epidemiología y Salud Pública, CIBERESP, Spain,Public Health Institute of Navarra, Pamplona, Spain4 aut |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Department of Surgery, Malmö University Hospital, Malmö, Sweden4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for Molecular Pathology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö Sweden,CREATE Health Center for Translational Cancer Research, Biomedical Center, Lund University, Lund, Sweden4 aut0 (Swepub:lu)pat-kji |
700 | 1 | a Van Guelpen, Bethanyu Umeå universitet,Patologi4 aut0 (Swepub:umu)beyvan99 |
700 | 1 | a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Spencer, Elizabeth A.u Cancer Epidemiology Unit, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Crowe, Francesca L.u Cancer Epidemiology Unit, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Khaw, Kay-Teeu Department of Public Health and Primary Care, University of Cambridge4 aut |
700 | 1 | a Wareham, Nicku Medical Research Council (MRC) Epidemiology Unit, Cambridge, UK4 aut |
700 | 1 | a Morois, Sophieu Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christineu Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France4 aut |
700 | 1 | a Clavel-Chapelon, Francoiseu Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France4 aut |
700 | 1 | a Chajes, Veroniqueu International Agency for Research on Cancer (IARC), Lyon, France4 aut |
700 | 1 | a Jenab, Mazdau International Agency for Research on Cancer (IARC), Lyon, France4 aut |
700 | 1 | a Boffetta, Paolou International Agency for Research on Cancer (IARC), Lyon, France4 aut |
700 | 1 | a Vineis, Paolou Cancer Epidemiology Department, University of Turin, Turin, Italy,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK4 aut |
700 | 1 | a Mouw, Traciu Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK4 aut |
700 | 1 | a Norat, Teresau Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK4 aut |
700 | 1 | a Riboli, Eliou Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK4 aut |
700 | 1 | a Nieters, Alexandrau German Cancer Research Center, Heidelberg, Germany,Centre of Chronic Immunodeficiency, University of Freiburg Medical Centre, Freiburg, Germany4 aut |
710 | 2 | a German Cancer Research Center, Heidelberg, Germanyb National Food Institute, Technical University of Denmark, Soborg, Denmark4 org |
773 | 0 | t Carcinogenesisd : Oxford University Press (OUP)g 31:3, s. 466-472q 31:3<466-472x 0143-3334x 1460-2180 |
856 | 4 | u http://dx.doi.org/10.1093/carcin/bgp325y FULLTEXT |
856 | 4 | u https://academic.oup.com/carcin/article-pdf/31/3/466/17288228/bgp325.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1589684 |
856 | 4 8 | u https://doi.org/10.1093/carcin/bgp325 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31571 |
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