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Death after awakeni...
Death after awakening from post-anoxic coma : The "best CPC" project
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- Taccone, Fabio Silvio (författare)
- Hospital Erasme,Université Libre de Bruxelles (ULB)
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- Horn, Janneke (författare)
- University of Amsterdam,Academic Medical Center of University of Amsterdam (AMC)
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- Storm, Christian (författare)
- Charité - University Medicine Berlin
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- Cariou, Alain (författare)
- Paris Descartes University,Cochin Hospital
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- Sandroni, Claudio (författare)
- Catholic University of the Sacred Heart, Rome,Policlinico Universitario Agostino Gemelli
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- Friberg, Hans (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital
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- Hoedemaekers, Cornelia Astrid (författare)
- Radboud University Nijmegen,Radboud University Medical Center
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- Oddo, Mauro (författare)
- Lausanne University Hospital
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(creator_code:org_t)
- 2019-04-03
- 2019
- Engelska.
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535. ; 23:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://ccforum.biom...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: In patients who recover consciousness after cardiac arrest (CA), a subsequent death from non-neurological causes may confound the assessment of long-term neurological outcome. We investigated the prevalence and causes of death after awakening (DAA) in a multicenter cohort of CA patients. Methods: Observational multicenter cohort study on patients resuscitated from CA in eight European intensive care units (ICUs) from January 2007 to December 2014. DAA during the hospital stay was extracted retrospectively from patient medical records. Demographics, comorbidities, initial CA characteristics, concomitant therapies, prognostic tests (clinical examination, electroencephalography (EEG), somatosensory evoked potentials (SSEPs)), and cause of death were identified. Results: From a total 4646 CA patients, 2478 (53%) died in-hospital, of whom 196 (4.2%; ranges 0.6-13.0%) had DAA. DAA was less frequent among out-of-hospital than in-hospital CA (82/2997 [2.7%] vs. 114/1649 [6.9%]; p < 0.001). Median times from CA to awakening and from awakening to death were 2 [1-5] and 9 [3-18] days, respectively. The main causes of DAA were multiple organ failure (n = 61), cardiogenic shock (n = 61), and re-arrest (n = 26). At day 3 from admission, results from EEG (n = 56) and SSEPs (n = 60) did not indicate poor outcome. Conclusions: In this large multicenter cohort, DAA was observed in 4.2% of non-survivors. Information on DAA is crucial since it may influence epidemiology and the design of future CA studies evaluating neuroprognostication and neuroprotection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Awakening
- Cardiac arrest
- Outcome
- Prognostication
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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