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Genomic imprinting ...
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Blunk, IngaLeibniz Institute for the Biology of Farm Animals (FBN)
(författare)
Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-07-14
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Springer Science and Business Media LLC,2020
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:4d928c3f-603a-433b-bad5-897b7612fbc4
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https://lup.lub.lu.se/record/4d928c3f-603a-433b-bad5-897b7612fbc4URI
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https://doi.org/10.1038/s41598-020-68212-xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on Swedish population-scale pedigree data. With P = 0.18 (T1D) and P = 0.26 (RA) imprinting variances were not significant. Explaining up to 19.00% (± 2.00%) and 15.00% (± 6.00%) of the phenotypic variance, the maternal environmental variance was significant for T1D (P = 1.60 × 10−24) and for RA (P = 0.02). For the first time, the existence of maternal genetic effects on RA was indicated, contributing up to 16.00% (± 3.00%) of the total variance. Environmental factors such as the social economic index, the number of offspring, birth year as well as their interactions with sex showed large effects.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Thomsen, HaukeGerman Cancer Research Centre,Genewerk GmbH(Swepub:lu)med-hth
(författare)
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Reinsch, NorbertLeibniz Institute for the Biology of Farm Animals (FBN)
(författare)
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Mayer, ManfredLeibniz Institute for the Biology of Farm Animals (FBN)
(författare)
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Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Hopp Children’s Cancer Center Heidelberg (KiTZ)(Swepub:lu)med-asf
(författare)
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Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai(Swepub:lu)med-jsu
(författare)
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Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Shimane University(Swepub:lu)med-ksq
(författare)
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Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Charles University in Prague(Swepub:lu)med-khk
(författare)
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Leibniz Institute for the Biology of Farm Animals (FBN)German Cancer Research Centre
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: Springer Science and Business Media LLC10:12045-2322
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