Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

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Fältnamn	Indikatorer	Metadata
000		08297naa a2201921 4500
001		oai:lup.lub.lu.se:4dfb7a40-0d3c-455b-88dc-e5f7bb96539c
003		SwePub
008		160401s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/17202902 URI
024	7	a https://doi.org/10.1016/j.jacc.2010.06.0222 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Assimes, Themistocles L.4 aut
245	1 0	a Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
264	1	b Elsevier BV,c 2010
520		a Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a myocardial
653		a kinesin-like protein 6
653		a coronary artery disease
653		a KIF6
653		a polymorphism
653		a infarction
700	1	a Holm, Hilma4 aut
700	1	a Kathiresan, Sekar4 aut
700	1	a Reilly, Muredach P.4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Voight, Benjamin F.4 aut
700	1	a Erdmann, Jeanette4 aut
700	1	a Willenborg, Christina4 aut
700	1	a Vaidya, Dhananjay4 aut
700	1	a Xie, Changchun4 aut
700	1	a Patterson, Chris C.4 aut
700	1	a Morgan, Thomas M.4 aut
700	1	a Burnett, Mary Susan4 aut
700	1	a Li, Mingyao4 aut
700	1	a Hlatky, Mark A.4 aut
700	1	a Knowles, Joshua W.4 aut
700	1	a Thompson, John R.4 aut
700	1	a Absher, Devin4 aut
700	1	a Iribarren, Carlos4 aut
700	1	a Go, Alan4 aut
700	1	a Fortmann, Stephen P.4 aut
700	1	a Sidney, Stephen4 aut
700	1	a Risch, Neil4 aut
700	1	a Tang, Hua4 aut
700	1	a Myers, Richard M.4 aut
700	1	a Berger, Klaus4 aut
700	1	a Stoll, Monika4 aut
700	1	a Shah, Svati H.4 aut
700	1	a Thorgeirsson, Gudmundur4 aut
700	1	a Andersen, Karl4 aut
700	1	a Havulinna, Aki S.4 aut
700	1	a Herrera, J. Enrique4 aut
700	1	a Faraday, Nauder4 aut
700	1	a Kim, Yoonhee4 aut
700	1	a Kral, Brian G.4 aut
700	1	a Mathias, Rasika A.4 aut
700	1	a Ruczinski, Ingo4 aut
700	1	a Suktitipat, Bhoom4 aut
700	1	a Wilson, Alexander F.4 aut
700	1	a Yanek, Lisa R.4 aut
700	1	a Becker, Lewis C.4 aut
700	1	a Linsel-Nitschke, Patrick4 aut
700	1	a Lieb, Wolfgang4 aut
700	1	a Koenig, Inke R.4 aut
700	1	a Hengstenberg, Christian4 aut
700	1	a Fischer, Marcus4 aut
700	1	a Stark, Klaus4 aut
700	1	a Reinhard, Wibke4 aut
700	1	a Winogradow, Janina4 aut
700	1	a Grassl, Martina4 aut
700	1	a Grosshennig, Anika4 aut
700	1	a Preuss, Michael4 aut
700	1	a Schreiber, Stefan4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Yee, Jean4 aut
700	1	a Friedlander, Yechiel4 aut
700	1	a Do, Ron4 aut
700	1	a Meigs, James B.4 aut
700	1	a Williams, Gordon4 aut
700	1	a Nathan, David M.4 aut
700	1	a MacRae, Calum A.4 aut
700	1	a Qu, Liming4 aut
700	1	a Wilensky, Robert L.4 aut
700	1	a Matthai, William H., Jr.4 aut
700	1	a Qasim, Atif N.4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Pichard, Augusto D.4 aut
700	1	a Kent, Kenneth M.4 aut
700	1	a Satler, Lowell4 aut
700	1	a Lindsay, Joseph M.4 aut
700	1	a Waksman, Ron4 aut
700	1	a Knouff, Christopher W.4 aut
700	1	a Waterworth, Dawn M.4 aut
700	1	a Walker, Max C.4 aut
700	1	a Mooser, Vincent E.4 aut
700	1	a Marrugat, Jaume4 aut
700	1	a Lucas, Gavin4 aut
700	1	a Subirana, Isaac4 aut
700	1	a Sala, Joan4 aut
700	1	a Ramos, Rafael4 aut
700	1	a Martinelli, Nicola4 aut
700	1	a Olivieri, Oliviero4 aut
700	1	a Trabetti, Elisabetta4 aut
700	1	a Malerba, Giovanni4 aut
700	1	a Pignatti, Pier Franco4 aut
700	1	a Guiducci, Candace4 aut
700	1	a Mirel, Daniel4 aut
700	1	a Parkin, Melissa4 aut
700	1	a Hirschhorn, Joel N.4 aut
700	1	a Asselta, Rosanna4 aut
700	1	a Duga, Stefano4 aut
700	1	a Musunuru, Kiran4 aut
700	1	a Daly, Mark J.4 aut
700	1	a Purcell, Shaun4 aut
700	1	a Eifert, Sandra4 aut
700	1	a Braund, Peter S.4 aut
700	1	a Wright, Benjamin J.4 aut
700	1	a Balmforth, Anthony J.4 aut
700	1	a Ball, Stephen G.4 aut
700	1	a Ouwehand, Willem H.4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Scholz, Michael4 aut
700	1	a Cambien, Francois4 aut
700	1	a Huge, Andreas4 aut
700	1	a Scheffold, Thomas4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Girelli, Domenico4 aut
700	1	a Granger, Christopher B.4 aut
700	1	a Peltonen, Leena4 aut
700	1	a McKeown, Pascal P.4 aut
700	1	a Altshuler, David4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Devaney, Joseph M.4 aut
700	1	a Epstein, Stephen E.4 aut
700	1	a Rader, Daniel J.4 aut
700	1	a Elosua, Roberto4 aut
700	1	a Engert, James C.4 aut
700	1	a Anand, Sonia S.4 aut
700	1	a Hall, Alistair S.4 aut
700	1	a Ziegler, Andreas4 aut
700	1	a O'Donnell, Christopher J.4 aut
700	1	a Spertus, John A.4 aut
700	1	a Siscovick, David4 aut
700	1	a Schwartz, Stephen M.4 aut
700	1	a Becker, Diane4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Schunkert, Heribert4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Quertermous, Thomas4 aut
710	2	a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
773	0	t Journal of the American College of Cardiologyd : Elsevier BVg 56:19, s. 1552-1563q 56:19<1552-1563x 0735-1097
856	4	u http://dx.doi.org/10.1016/j.jacc.2010.06.022y FULLTEXT
856	4	u https://doi.org/10.1016/j.jacc.2010.06.022
856	4 8	u https://lup.lub.lu.se/record/1720290
856	4 8	u https://doi.org/10.1016/j.jacc.2010.06.022

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Av författaren/redakt...: Assimes, Themist ...; Holm, Hilma; Kathiresan, Seka ...; Reilly, Muredach ...; Thorleifsson, Gu ...; Voight, Benjamin ...; visa fler...; Erdmann, Jeanett ...; Willenborg, Chri ...; Vaidya, Dhananja ...; Xie, Changchun; Patterson, Chris ...; Morgan, Thomas M ...; Burnett, Mary Su ...; Li, Mingyao; Hlatky, Mark A.; Knowles, Joshua ...; Thompson, John R ...; Absher, Devin; Iribarren, Carlo ...; Go, Alan; Fortmann, Stephe ...; Sidney, Stephen; Risch, Neil; Tang, Hua; Myers, Richard M ...; Berger, Klaus; Stoll, Monika; Shah, Svati H.; Thorgeirsson, Gu ...; Andersen, Karl; Havulinna, Aki S ...; Herrera, J. Enri ...; Faraday, Nauder; Kim, Yoonhee; Kral, Brian G.; Mathias, Rasika ...; Ruczinski, Ingo; Suktitipat, Bhoo ...; Wilson, Alexande ...; Yanek, Lisa R.; Becker, Lewis C.; Linsel-Nitschke, ...; Lieb, Wolfgang; Koenig, Inke R.; Hengstenberg, Ch ...; Fischer, Marcus; Stark, Klaus; Reinhard, Wibke; Winogradow, Jani ...; Grassl, Martina; Grosshennig, Ani ...; Preuss, Michael; Schreiber, Stefa ...; Wichmann, H-Eric ...; Meisinger, Chris ...; Yee, Jean; Friedlander, Yec ...; Do, Ron; Meigs, James B.; Williams, Gordon; Nathan, David M.; MacRae, Calum A.; Qu, Liming; Wilensky, Robert ...; Matthai, William ...; Qasim, Atif N.; Hakonarson, Hako ...; Pichard, Augusto ...; Kent, Kenneth M.; Satler, Lowell; Lindsay, Joseph ...; Waksman, Ron; Knouff, Christop ...; Waterworth, Dawn ...; Walker, Max C.; Mooser, Vincent ...; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Martinelli, Nico ...; Olivieri, Olivie ...; Trabetti, Elisab ...; Malerba, Giovann ...; Pignatti, Pier F ...; Guiducci, Candac ...; Mirel, Daniel; Parkin, Melissa; Hirschhorn, Joel ...; Asselta, Rosanna; Duga, Stefano; Musunuru, Kiran; Daly, Mark J.; Purcell, Shaun; Eifert, Sandra; Braund, Peter S.; Wright, Benjamin ...; Balmforth, Antho ...; Ball, Stephen G.; Ouwehand, Willem ...; Deloukas, Panos; Scholz, Michael; Cambien, Francoi ...; Huge, Andreas; Scheffold, Thoma ...; Salomaa, Veikko; Girelli, Domenic ...; Granger, Christo ...; Peltonen, Leena; McKeown, Pascal ...; Altshuler, David; Melander, Olle; Devaney, Joseph ...; Epstein, Stephen ...; Rader, Daniel J.; Elosua, Roberto; Engert, James C.; Anand, Sonia S.; Hall, Alistair S ...; Ziegler, Andreas; O'Donnell, Chris ...; Spertus, John A.; Siscovick, David; Schwartz, Stephe ...; Becker, Diane; Thorsteinsdottir ...; Stefansson, Kari; Schunkert, Herib ...; Samani, Nilesh J ...; Quertermous, Tho ...; visa färre...

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