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Sex differences in ...
Sex differences in multilayer functional network topology over the course of aging in 37543 UK Biobank participants
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- Mijalkov, Mite (författare)
- Karolinska Institutet,Karolinska Institute
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- Veréb, Dániel (författare)
- Karolinska Institutet,Karolinska Institute
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- Jamialahmadi, Oveis (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Canal-Garcia, Anna (författare)
- Karolinska Institutet,Karolinska Institute
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- Gómez-Ruiz, Emiliano (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för fysik (GU),Department of Physics (GU)
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- Vidal-Piñeiro, Didac (författare)
- University of Oslo
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- Romeo, Stefano, 1976 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,University Magna Graecia,Center for Cardiovascular and Metabolic Research (CMR)
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- Volpe, Giovanni, 1979 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för fysik (GU),Department of Physics (GU)
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- Pereira, Joana B. (författare)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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(creator_code:org_t)
- 2023-01-01
- 2023
- Engelska 26 s.
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Ingår i: Network Neuroscience. - : MIT Press. - 2472-1751. ; 7:1, s. 351-376
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Aging is a major risk factor for cardiovascular and neurodegenerative disorders, with considerable societal and economic implications. Healthy aging is accompanied by changes in functional connectivity between and within resting-state functional networks, which have been associated with cognitive decline. However, there is no consensus on the impact of sex on these age-related functional trajectories. Here, we show that multilayer measures provide crucial information on the interaction between sex and age on network topology, allowing for better assessment of cognitive, structural, and cardiovascular risk factors that have been shown to differ between men and women, as well as providing additional insights into the genetic influences on changes in functional connectivity that occur during aging. In a large crosssectional sample of 37,543 individuals from the UK Biobank cohort, we demonstrate that such multilayer measures that capture the relationship between positive and negative connections are more sensitive to sex-related changes in the whole-brain connectivity patterns and their topological architecture throughout aging, when compared to standard connectivity and topological measures. Our findings indicate that multilayer measures contain previously unknown information on the relationship between sex and age, which opens up new avenues for research into functional brain connectivity in aging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Aging
- Anti-correlations
- Functional connectivity
- Multilayer networks
- Sex differences
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Mijalkov, Mite
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Veréb, Dániel
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Jamialahmadi, Ov ...
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Canal-Garcia, An ...
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Gómez-Ruiz, Emil ...
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Vidal-Piñeiro, D ...
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visa fler...
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Romeo, Stefano, ...
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Volpe, Giovanni, ...
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Pereira, Joana B ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Gerontologi medi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Network Neurosci ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet
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Göteborgs universitet