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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03450naa a2200445 4500 | |
| 001 | oai:lup.lub.lu.se:4fe140c5-7ee2-421b-b7ad-8f5f68492c3b | |
| 003 | SwePub | |
| 008 | 160401s2004 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:liu-22314 | |
| 024 | 7 | a https://lup.lub.lu.se/record/2767922 URI |
| 024 | 7 | a https://doi.org/10.1016/j.bbrc.2004.04.1102 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-223142 URI |
| 040 | a (SwePub)lud (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Jönsson, Maria,d 1977-u Linköpings universitet,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi4 aut0 (Swepub:liu)marjo70 |
| 245 | 1 0 | a FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor Fox03 |
| 264 | 1 | b Elsevier BV,c 2004 |
| 520 | a Proliferation, differentiation, and survival of hematopoietic cells are regulated by cytokines, acting through specific receptors. FLT3 ligand (FL) is one of the most important cytokines for regulation of the hematopoietic system, and its receptor FLT3 is expressed on both stem cells and progenitors. Regulation of Forkhead transcription factors has been described as an important mechanism to control apoptosis and cell cycle progression in hematopoietic progenitors. Here we report that FL induces AKT/PKB activation, which in turn phosphorylates and thereby inactivates the Forkhead protein FoxO3 in the progenitor cell line FDC-P1 stably expressing murine FLT3 receptor. Phosphorylation of AKT and FoxO3 was blocked by the PI-3 kinase inhibitor LY294002 but not by the MAP kinase inhibitor PD98059. Expression of a mutated FoxO3, in which all three inhibitory phosphorylation sites were mutated to alanine, led to rapid increase of apoptotic cells in the presence of FL. These results suggest that FL-induced regulation of apoptosis is executed by FoxO3. (C) 2004 Elsevier Inc. All rights reserved. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 653 | a survival | |
| 653 | a signaling | |
| 653 | a FLT3 | |
| 653 | a hematopoiesis | |
| 653 | a cytokines | |
| 653 | a AKT | |
| 653 | a forkhead | |
| 653 | a MEDICINE | |
| 700 | 1 | a Kraft, Mariau Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-men |
| 700 | 1 | a Jönsson, Jan-Ingvaru Linköpings universitet,Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi4 aut0 (Swepub:liu)janjo86 |
| 700 | 1 | a Engström, Maria,d 1973-u Linköpings universitet,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi4 aut0 (Swepub:liu)maren42 |
| 710 | 2 | a Linköpings universitetb Hälsouniversitetet4 org |
| 773 | 0 | t Biochemical and Biophysical Research Communicationsd : Elsevier BVg 318:4, s. 899-903q 318:4<899-903x 1090-2104x 0006-291X |
| 856 | 4 | u http://dx.doi.org/10.1016/j.bbrc.2004.04.110y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/276792 |
| 856 | 4 8 | u https://doi.org/10.1016/j.bbrc.2004.04.110 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-22314 |
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