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A practical and env...
A practical and environmentally friendly protocol for synthesis of α-deuterated carboxylic acids
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- Wennerberg, Johan (författare)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Red Glead Discovery AB
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- Dreisch, Klaus (författare)
- Red Glead Discovery AB
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(creator_code:org_t)
- 2023-03-02
- 2023
- Engelska 7 s.
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Ingår i: Journal of Labelled Compounds and Radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 66:4-6, s. 138-144
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- α-deuterated carboxylic acids have been synthesized from the corresponding malonic acids via hydrogen/deuterium exchange and decarboxylation in presence of D2O. The method is general, mild and efficient and does not require organic solvents or other additives. Yields range between 83% and 94% and purification was not necessary. Starting materials were easy accessible and the α-deuterated carboxylic acids may easily be transformed to other labeled compounds such as alcohols, aldehydes, esters, and amides. Characterization with NMR confirmed purity and isotopic purity.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- H labeling
- decarboxylation
- malonic acids
- α-deuterated carboxylic acid
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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