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Integrin α10, a nov...
Integrin α10, a novel therapeutic target in glioblastoma, regulates cell migration, proliferation, and survival
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- Thorén, Matilda Munksgaard (författare)
- Xintela AB, SE-22381 Lund, Sweden
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- Masoumi, Katarzyna Chmielarska (författare)
- Xintela AB, SE-22381 Lund, Sweden
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- Krona, Cecilia, 1976- (författare)
- Uppsala universitet,Uppsala University,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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- Huang, Xiaoli (författare)
- Xintela AB, SE-22381 Lund, Sweden
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- Kundu, Soumi (författare)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Schmidt, Linnéa (författare)
- Xintela AB, SE-22381 Lund, Sweden
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- Forsberg Nilsson, Karin, 1963- (författare)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Keep, Marcus Floyd (författare)
- University of North Dakota,Sanford Brain & Spine Inst, Dept Neurosurg, Fargo, ND 58102 USA;Univ North Dakota, Sch Med, Dept Surg, Fargo, ND 58102 USA
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- Englund, Elisabet (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Neuropathol Lab, SE-22184 Lund, Sweden
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- Nelander, Sven (författare)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Holmqvist, Bo (författare)
- ImaGene iT AB, SE-22381 Lund, Sweden
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- Lundgren-Åkerlund, Evy (författare)
- Xintela AB, SE-22381 Lund, Sweden
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(creator_code:org_t)
- 2019-04-25
- 2019
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 11:4
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- New, effective treatment strategies for glioblastomas (GBMs), the most malignant and invasive brain tumors in adults, are highly needed. In this study, we investigated the potential of integrin α10Β1 as a therapeutic target in GBMs. Expression levels and the role of integrin α10Β1 were studied in patient-derived GBM tissues and cell lines. The effect of an antibody-drug conjugate (ADC), an integrin a10 antibody conjugated to saporin, on GBM cells and in a xenograft mouse model was studied. We found that integrin α10Β1 was strongly expressed in both GBM tissues and cells, whereas morphologically unaffected brain tissues showed only minor expression. Partial or no overlap was seen with integrins α3, α6, and α7, known to be expressed in GBM. Further analysis of a subpopulation of GBM cells selected for high integrin α10 expression demonstrated increased proliferation and sphere formation. Additionally, siRNA-mediated knockdown of integrin α10 in GBM cells led to decreased migration and increased cell death. Furthermore, the ADC reduced viability and sphere formation of GBM cells and induced cell death both in vitro and in vivo. Our results demonstrate that integrin α10Β1 has a functional role in GBM cells and is a novel, potential therapeutic target for the treatment of GBM.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- Antibody-drug conjugate (ADC)
- Glioblastoma (GBM)
- Glioma
- Integrin α10
- Saporin
- glioblastoma (GBM)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Cancers
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Till lärosätets databas
- Av författaren/redakt...
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Thorén, Matilda ...
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Masoumi, Katarzy ...
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Krona, Cecilia, ...
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Huang, Xiaoli
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Kundu, Soumi
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Schmidt, Linnéa
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visa fler...
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Forsberg Nilsson ...
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Keep, Marcus Flo ...
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Englund, Elisabe ...
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Nelander, Sven
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Holmqvist, Bo
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Lundgren-Åkerlun ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Lunds universitet
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Uppsala universitet