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Group Selection and...
Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype.
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Bordería, Antonio V (författare)
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Isakov, Ofer (författare)
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Moratorio, Gonzalo (författare)
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- Henningsson, Rasmus (författare)
- Lund University,Lunds universitet,Matematik LTH,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Mathematics (Faculty of Engineering),Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH
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Agüera-González, Sonia (författare)
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Organtini, Lindsey (författare)
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Gnädig, Nina F (författare)
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Blanc, Hervé (författare)
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Alcover, Andrés (författare)
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Hafenstein, Susan (författare)
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- Fontes, Magnus (författare)
- Lund University,Lunds universitet,Matematik LTH,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Mathematics (Faculty of Engineering),Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH
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Shomron, Noam (författare)
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Vignuzzi, Marco (författare)
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(creator_code:org_t)
- 2015-05-05
- 2015
- Engelska.
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Ingår i: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7366 .- 1553-7374. ; 11:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Understanding how a pathogen colonizes and adapts to a new host environment is a primary aim in studying emerging infectious diseases. Adaptive mutations arise among the thousands of variants generated during RNA virus infection, and identifying these variants will shed light onto how changes in tropism and species jumps can occur. Here, we adapted Coxsackie virus B3 to a highly permissive and less permissive environment. Using deep sequencing and bioinformatics, we identified a multi-step adaptive process to adaptation involving residues in the receptor footprints that correlated with receptor availability and with increase in virus fitness in an environment-specific manner. We show that adaptation occurs by selection of a dominant mutation followed by group selection of minority variants that together, confer the fitness increase observed in the population, rather than selection of a single dominant genotype.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bordería, Antoni ...
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Isakov, Ofer
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Moratorio, Gonza ...
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Henningsson, Ras ...
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Agüera-González, ...
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Organtini, Linds ...
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visa fler...
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Gnädig, Nina F
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Blanc, Hervé
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Alcover, Andrés
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Hafenstein, Susa ...
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Fontes, Magnus
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Shomron, Noam
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Vignuzzi, Marco
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
- Artiklar i publikationen
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PLoS Pathogens
- Av lärosätet
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Lunds universitet