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Genotoxic effects o...
Genotoxic effects of daily personal exposure to particle mass and number concentrations on buccal cells
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- de Almeida, Daniela S. (författare)
- State University of Maringá,Federal Technological University Of Paraná
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- da Costa, Silvano César (författare)
- State University of Londrina
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- Ribeiro, Marcos (författare)
- State University of Londrina
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- Moreira, Camila A.B. (författare)
- Federal Technological University Of Paraná
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- Beal, Alexandra (författare)
- State University of Londrina
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- Squizzato, Rafaela (författare)
- Federal Technological University Of Paraná
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- Rudke, Anderson Paulo (författare)
- Federal Technological University Of Paraná
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- Rafee, Sameh Adib Abou (författare)
- University of São Paulo
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- Martins, Jorge A. (författare)
- Lund University,Lunds universitet,Avdelningen för Teknisk vattenresurslära,Institutionen för bygg- och miljöteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Water Resources Engineering,Department of Building and Environmental Technology,Departments at LTH,Faculty of Engineering, LTH,Federal Technological University Of Paraná
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- Palioto, Graciana Freitas (författare)
- Federal Technological University Of Paraná
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- Kumar, Prashant (författare)
- University of Surrey
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- Martins, Leila D. (författare)
- Lund University,Lunds universitet,Avdelningen för Teknisk vattenresurslära,Institutionen för bygg- och miljöteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Water Resources Engineering,Department of Building and Environmental Technology,Departments at LTH,Faculty of Engineering, LTH,Federal Technological University Of Paraná
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska 10 s.
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Ingår i: Atmospheric Environment. - : Elsevier BV. - 1352-2310. ; 176, s. 148-157
- Relaterad länk:
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http://dx.doi.org/10...
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https://surrey-resea...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study is to assess personal exposure to Particle Number Concentrations (PNC) in four size ranges between 0.3 and 10 μm, and particulate matter (PM1; PM2.5; PM4; PM10) in order to evaluate possible genotoxic effects through a comet assay in buccal cells. A convenience cohort of 30 individuals from a Brazilian medium-sized city was selected. These individuals aged between 20 and 61 and worked in typical job categories (i.e., administrative, commerce, education, general services and transport). They were recruited to perform personal exposure measurements during their typical daily routine activities, totaling 240 h of sampling. The 8-h average mass concentrations in air for volunteers ranged from 2.4 to 31.8 μg m−3 for PM1, 4.2–45.1 μg m−3 for PM2.5, 7.9–66.1 μg m−3 for PM4 and from 23.1 to 131.7 μg m−3 for PM10. The highest PNC variation was found for 0.3–0.5 range, between 14 and 181 particles cm−3, 1 to 14 particles cm−3 for the 0.5–1.0 range, 0.2 to 2 particles cm−3 for the 1.0–2.5 range, and 0.06 to 0.7 particles cm−3 for the 2.5–10 range. Volunteers in the ‘education’ category experienced the lowest inhaled dose of PM2.5 as opposed to those involved in ‘commercial‘ activities with the highest doses for PM10 (1.63 μg kg−1 h−1) and PM2.5 (0.61 μg kg−1 h−1). The predominant cause for these high doses was associated with the proximity of the workplace to the street and vehicle traffic. The comet assay performed in buccal cells indicated that the volunteers in ‘commerce’ category experienced the highest damage to their DeoxyriboNucleic Acid (DNA) compared with the control category (i.e. ‘education’). These results indicate the variability in personal exposure of the volunteers in different groups, and the potential damage to DNA was much higher for those spending time in close proximity to the vehicle sources (e.g. commercial services) leading to exposure to a higher fraction of fine particles. This study builds understanding on the exposure of people in different job categories, and provide policy makers with useful information to tackle this neglected issue.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Air pollution
- DNA damage
- Fine particulate matter
- Personal exposure
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de Almeida, Dani ...
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da Costa, Silvan ...
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Ribeiro, Marcos
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Moreira, Camila ...
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Beal, Alexandra
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Squizzato, Rafae ...
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Rudke, Anderson ...
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Rafee, Sameh Adi ...
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Martins, Jorge A ...
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Palioto, Gracian ...
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Kumar, Prashant
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Martins, Leila D ...
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