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Increased magnitude...
Increased magnitude of relaxation to oestrogen in aorta from oestrogen receptor beta knock-out mice
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- Nilsson, B O (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Ekblad, E (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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Heine, T (författare)
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- Gustafsson, J-Å (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Bioscientifica, 2000
- 2000
- Engelska.
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Ingår i: Journal of Endocrinology. - : Bioscientifica. - 0022-0795 .- 1479-6805. ; 166:2, s. 5-9
- Relaterad länk:
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Micromolar concentrations of the biologically active oestrogen 17beta-oestradiol reduce agonist-induced force in vascular preparations through an unidentified mechanism. The aim of the present study was to investigate the importance of oestrogen receptor beta (ERbeta) for oestrogen-induced vascular relaxation. 17beta-oestradiol was added to aortic rings from ERbeta knock-out (-/-) and wild-type (+/+) mice precontracted with noradrenaline. 17beta-oestradiol caused a concentration-dependent (1-100 microM) relaxation of aortic rings from both -/- and +/+ animals of both sexes. Rings from male and female -/- mice were more sensitive to 17beta-oestradiol than those from +/+ mice. Medial thickness, determined by computerized image analysis, was similar in rings from -/- and +/+ animals. Endothelium, as determined by immuno-cytochemistry, was present in -/- and +/+ aorta. Maximal noradrenaline evoked force and sensitivity to noradrenaline were similar in both groups. In summary ERbeta modulates vascular relaxation to microM concentrations of oestrogen; lack of ERbeta renders the vascular wall supersensitive to 17beta-oestradiol. Lack of ERbeta caused no change in vascular wall morphology suggesting that this ER subtype is not involved in vascular structure development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Animals
- Aorta
- Body Weight
- Dose-Response Relationship, Drug
- Endothelium, Vascular
- Estradiol
- Estrogen Receptor beta
- Female
- Image Processing, Computer-Assisted
- Immunohistochemistry
- In Vitro Techniques
- Male
- Mice
- Mice, Knockout
- Microscopy, Fluorescence
- Muscle, Smooth, Vascular
- Norepinephrine
- Receptors, Estrogen
- Vasoconstriction
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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