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Roles of adiponecti...
Roles of adiponectin and leptin signaling-related micrornas in the preventive effects of calorie restriction in mammary tumor development
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- Dogan, Soner (författare)
- Yeditepe University
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- Cicekdal, Munevver B. (författare)
- Ghent University,Yeditepe University
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- Ozorhan, Umit (författare)
- University of Lübeck
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- Karabiyik, Goktug (författare)
- Yeditepe University
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- Kazan, Busra T. (författare)
- Yeditepe University
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- Ekici, Isin D. (författare)
- Yeditepe University
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- Yilmaz, Bayram (författare)
- Yeditepe University
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- Demirel, Pinar B. (författare)
- Maltepe University
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- Coban, Ilker (författare)
- Yeditepe University
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- Tuysuz, Emre Can (författare)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups
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- Kuskucu, Aysegul (författare)
- Yeditepe University
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- Bayrak, Omer F. (författare)
- Yeditepe University
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- Cleary, Margot P. (författare)
- University of Minnesota
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- Tuna, Bilge G. (författare)
- Yeditepe University
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(creator_code:org_t)
- Canadian Science Publishing, 2021
- 2021
- Engelska 11 s.
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Ingår i: Applied Physiology, Nutrition and Metabolism. - : Canadian Science Publishing. - 1715-5312 .- 1715-5320. ; 46:8, s. 866-876
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Calorie restriction (CR) is suggested to prevent the development of mammary tumors (MTs); however, the mechanism remains to be clarified. We aimed to determine the microRNA (miRNA) profile in mice applied to 2 different CR protocols; chronic (CCR) and intermittent (ICR) and follow the MT development. In addition, the roles of miRNAs involved in adiponectin and/or leptin signaling pathways were investigated. Mice were divided into 3 groups: ad-libitum (AL), CCR, or ICR, which comprised 3 weeks of AL feeding followed by 1 week of 60% CR in a cyclic manner. Blood and tissue collection were performed at weeks 10, 17/18, 49/50 and 81/82. Long-term CCR provided better protection compared with ICR for MT development with a delay in the MT occurrence. Adiponectin expression in mammary fat pad were significantly higher in CCR group compared with AL. Using GeneChip Array, 250 of 3195 miRNAs were differentially expressed among the dietary groups. Thirteen of 250 miRNAs were related to adiponectin and/or leptin signaling genes. Results were verified by reverse transcription polymerase chain reaction. Specifically, miR-326-3p, miR-500-3p and miR-129-5p, which are related to adiponectin and/or leptin signaling, may play important roles in the preventive effects of CR in MT development and in ageing. Thus, these miRNAs might be putative biomarkers to target for diagnostic and treatment purposes. Novelty: Type of CR and micro RNA interaction is related to ageing. miR-326-3p, miR-500-3p and miR-129-5p expression levels were differentially expressed in MT development and in ageing. The genes associated with adiponectin and/or leptin signaling pathways are regulated by certain miRNAs in the protective effects of CR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Adipokines
- Ageing
- Intermittent calorie restriction
- Mammary tumor
- MiRNA
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Dogan, Soner
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Cicekdal, Munevv ...
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Ozorhan, Umit
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Karabiyik, Goktu ...
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Kazan, Busra T.
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Ekici, Isin D.
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visa fler...
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Yilmaz, Bayram
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Demirel, Pinar B ...
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Coban, Ilker
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Tuysuz, Emre Can
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Kuskucu, Aysegul
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Bayrak, Omer F.
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Cleary, Margot P ...
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Tuna, Bilge G.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Applied Physiolo ...
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Lunds universitet