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HTLV-1 in rural Gui...
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van Tienen, Carla
(författare)
HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-06-04
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Springer Science and Business Media LLC,2010
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:53b140ed-18cb-4c9b-b8de-0bd10bb7d7a7
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https://lup.lub.lu.se/record/1657738URI
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https://doi.org/10.1186/1742-4690-7-50DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Background: HTLV-1 is endemic in Guinea-Bissau, and the highest prevalence in the adult population (5.2%) was observed in a rural area, Caio, in 1990. HIV-1 and HIV-2 are both prevalent in this area as well. Cross-sectional associations have been reported for HTLV-1 with HIV infection, but the trends in prevalence of HTLV-1 and HIV associations are largely unknown, especially in Sub Saharan Africa. In the current study, data from three cross-sectional community surveys performed in 1990, 1997 and 2007, were used to assess changes in HTLV-1 prevalence, incidence and its associations with HIV-1 and HIV-2 and potential risk factors. Results: HTLV-1 prevalence was 5.2% in 1990, 5.9% in 1997 and 4.6% in 2007. Prevalence was higher among women than men in all 3 surveys and increased with age. The Odds Ratio (OR) of being infected with HTLV-1 was significantly higher for HIV positive subjects in all surveys after adjustment for potential confounding factors. The risk of HTLV-1 infection was higher in subjects with an HTLV-1 positive mother versus an uninfected mother (OR 4.6, CI 2.6-8.0). The HTLV-1 incidence was stable between 1990-1997 (Incidence Rate (IR) 1.8/1,000 pyo) and 1997-2007 (IR 1.6/1,000 pyo) (Incidence Rate Ratio (IRR) 0.9, CI 0.4-1.7). The incidence of HTLV-1 among HIV-positive individuals was higher compared to HIV negative individuals (IRR 2.5, CI 1.0-6.2), while the HIV incidence did not differ by HTLV-1 status (IRR 1.2, CI 0.5-2.7). Conclusions: To our knowledge, this is the largest community based study that has reported on HTLV-1 prevalence and associations with HIV. HTLV-1 is endemic in this rural community in West Africa with a stable incidence and a high prevalence. The prevalence increases with age and is higher in women than men. HTLV-1 infection is associated with HIV infection, and longitudinal data indicate HIV infection may be a risk factor for acquiring HTLV-1, but not vice versa. Mother to child transmission is likely to contribute to the epidemic.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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van der Loeff, Maarten F. Schim
(författare)
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Peterson, Ingrid
(författare)
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Cotten, Matthew
(författare)
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Holmgren, Birgitta GLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-bho
(författare)
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Andersson, Soren
(författare)
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Vincent, Tim
(författare)
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Sarge-Njie, Ramu
(författare)
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Rowland-Jones, Sarah
(författare)
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Jaye, Assan
(författare)
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Aaby, Peter
(författare)
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Whittle, Hilton
(författare)
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Avdelningen för medicinsk mikrobiologiInstitutionen för laboratoriemedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Retrovirology: Springer Science and Business Media LLC71742-4690
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van Tienen, Carl ...
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van der Loeff, M ...
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Peterson, Ingrid
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Cotten, Matthew
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Holmgren, Birgit ...
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Andersson, Soren
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visa fler...
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Vincent, Tim
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Sarge-Njie, Ramu
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Rowland-Jones, S ...
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Jaye, Assan
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Aaby, Peter
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Whittle, Hilton
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Mikrobiologi ino ...
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Retrovirology
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Lunds universitet