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Childhood Height Gr...
Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes
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- Li, Zhiguo (författare)
- IBM Thomas J. Watson Research Center
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- Veijola, Riitta (författare)
- University of Oulu,Oulu University Hospital
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- Koski, Eileen (författare)
- IBM Thomas J. Watson Research Center
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- Anand, Vibha (författare)
- IBM Thomas J. Watson Research Center
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- Martin, Frank (författare)
- Juvenile Diabetes Research Foundation
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- Waugh, Kathleen (författare)
- University of Colorado
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- Hyöty, Heikki (författare)
- University of Tampere
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- Winkler, Christiane (författare)
- Helmholtz Zentrum München
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- Killian, Michael B. (författare)
- Pacific Northwest Research Institute
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- Lundgren, Markus (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad
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- Ng, Kenney (författare)
- IBM Thomas J. Watson Research Center
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- Maziarz, Marlena (författare)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Toppari, Jorma (författare)
- Turku University Hospital
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IBM Thomas J Watson Research Center University of Oulu (creator_code:org_t)
- 2022-03-04
- 2022
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:6, s. 1520-1528
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Context: Rapid growth has been suggested to promote islet autoimmunity and progression to type 1 diabetes (T1D). Childhood growth has not been analyzed separately from the infant growth period in most previous studies, but it may have distinct features due to differences between the stages of development. Objective: We aimed to analyze the association of childhood growth with development of islet autoimmunity and progression to T1D diagnosis in children 1 to 8 years of age. Methods: Longitudinal data of childhood growth and development of islet autoimmunity and T1D were analyzed in a prospective cohort study including 10 145 children from Finland, Germany, Sweden, and the United States, 1-8 years of age with at least 3 height and weight measurements and at least 1 measurement of islet autoantibodies. The primary outcome was the appearance of islet autoimmunity and progression from islet autoimmunity to T1D. Results: Rapid increase in height (cm/year) was associated with increased risk of seroconversion to glutamic acid decarboxylase autoantibody, insulin autoantibody, or insulinoma-like antigen-2 autoantibody (hazard ratio [HR] = 1.26 [95% CI = 1.05, 1.51] for 1-3 years of age and HR = 1.48 [95% CI = 1.28, 1.73] for >3 years of age). Furthermore, height rate was positively associated with development of T1D (HR = 1.80 [95% CI = 1.15, 2.81]) in the analyses from seroconversion with insulin autoantibody to diabetes. Conclusion: Rapid height growth rate in childhood is associated with increased risk of islet autoimmunity and progression to T1D. Further work is needed to investigate the biological mechanism that may explain this association.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- autoantibodies
- child growth
- prospective cohort
- type 1 diabetes
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Li, Zhiguo
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Veijola, Riitta
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Koski, Eileen
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Anand, Vibha
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Martin, Frank
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Waugh, Kathleen
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visa fler...
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Hyöty, Heikki
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Winkler, Christi ...
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Killian, Michael ...
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Lundgren, Markus
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Ng, Kenney
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Maziarz, Marlena
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Toppari, Jorma
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