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The late stage of P...
The late stage of Parkinson's –results of a large multinational study on motor and non-motor complications
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- Schrag, A. (författare)
- University College London
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- Hommel, A. L.A.J. (författare)
- Radboud University Medical Center
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- Lorenzl, S. (författare)
- University Hospital Munich
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- Meissner, W. G. (författare)
- University of Bordeaux,Centre Hospitalier Universitaire de Bordeaux,University of Otago
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- Odin, P. (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Coelho, M. (författare)
- University of Lisbon
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- Bloem, B. R. (författare)
- Radboud University Medical Center
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- Dodel, R. (författare)
- Philipp University of Marburg,University Hospital Essen
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(creator_code:org_t)
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- Elsevier BV, 2020
- 2020
- Engelska 6 s.
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Ingår i: Parkinsonism and Related Disorders. - : Elsevier BV. - 1353-8020. ; 75, s. 91-96
- Relaterad länk:
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http://dx.doi.org/10...
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https://repository.u...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: There is little information on the late stages of parkinsonism. Methods: We conducted a multicentre study in 692 patients with late stage parkinsonism in six European countries. Inclusion criteria were disease duration of ≥7 years and either Hoehn and Yahr stage ≥4 or Schwab and England score of 50 or less. Results: Average disease duration was 15.4 (SD 7.7) years and mean total UPDRS score was 82.7 (SD 22.4). Dementia according to MDS-criteria was present in 37% of patients. Mean levodopa equivalence dose was 874.1 (SD 591.1) mg/d. Eighty two percent of patients reported falls, related to freezing (16%) or unrelated to freezing (21% of patients) or occurring both related and unrelated to freezing (45%), and were frequent in 26%. Moderate-severe difficulties were reported for turning in bed by 51%, speech by 43%, swallowing by 16% and tremor by 11%. Off-periods occurred in 68% and were present at least 50% of the day in 13%, with morning dystonia occurring in 35%. Dyskinesias were reported by 45% but were moderate or severe only in 7%. Moderate-severe fatigue, constipation, urinary symptoms and nocturia, concentration and memory problems were encountered by more than half of participants. Hallucinations (44%) or delusions (25%) were present in 63% and were moderate-severe in 15%. The association with overall disability was strongest for severity of falls/postural instability, bradykinesia, cognitive score and speech impairment. Conclusion: These data suggest that current treatment of late stage parkinsonism in the community remains insufficiently effective to alleviate disabling symptoms in many patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Disability
- Late-stage parkinsonism
- Motor features
- Non-motor symptoms
- Prevalence
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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