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Sökning: onr:"swepub:oai:lup.lub.lu.se:56b1ed1a-1c21-494d-92d1-9cfbadf6785d" > Distinct and overla...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004627naa a2200397 4500
001oai:lup.lub.lu.se:56b1ed1a-1c21-494d-92d1-9cfbadf6785d
003SwePub
008160404s2009 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:118188487
0247 a https://lup.lub.lu.se/record/12894902 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1181884872 URI
0247 a https://doi.org/10.4049/jimmunol.182.3.14602 DOI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Cheng, Minu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-mnc
2451 0a Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.
264 1b The American Association of Immunologists,c 2009
520 a Although bone marrow (BM) represents the main site for postnatal NK cell development, recently a distinct thymic-dependent NK cell pathway was identified. These studies were designed to investigate the role of cytokines in regulation of thymic NK cells and to compare with established regulatory pathways of BM-dependent NK cell compartment. The common cytokine receptor gamma-chain (Il2rg) essential for IL-15-induced signaling, and FMS-like tyrosine kinase 3 (FLT3) receptor ligand (Flt3l) were previously identified as important regulatory pathways of the BM NK cell compartment based on lack of function studies in mice, however their complementary action remains unknown. By investigating mice double-deficient in Il2rg and Flt3l (Flt3l(-/-) Il2rg(-/-)), we demonstrate that FLT3L is important for IL2Rg-independent maintenance of both immature BM as well as peripheral NK cells. In contrast to IL-7, which is dispensable for BM but important for thymic NK cells, IL-15 has a direct and important role in both thymic and BM NK cell compartments. Although thymic NK cells were not affected in Flt3l(-/-) mice, Flt3l(-/-)Il2rg(-/-) mice lacked detectable thymic NK cells, suggesting that FLT3L is also important for IL-2Rg-independent maintenance of thymic NK cells. Thus, IL-2Rg cytokines and FLT3L play complementary roles and are indispensable for homeostasis of both BM and thymic dependent NK cell development, suggesting that the cytokine pathways crucial for these two distinct NK cell pathways are largely overlapping.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a NozadCharoudeh, Hojjatollahu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-hln
7001 a Brodin, Petteru Karolinska Institutet4 aut
7001 a Tang, Yanjuan4 aut
7001 a Lakshmikanth, Tadepallyu Karolinska Institutet4 aut
7001 a Höglund, Petteru Karolinska Institutet4 aut
7001 a Jacobsen, Sten Eirik Wu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,University of Oxford4 aut0 (Swepub:lu)stem-sja
7001 a Sitnicka Quinn, Ewau Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-esi
7102 a Stamcellscentrum (SCC)b Avdelningen för stamcellsforskning4 org
7730 t Journal of immunologyd : The American Association of Immunologistsg 182:3, s. 1460-1468q 182:3<1460-1468x 1550-6606x 0022-1767
8564 u http://www.ncbi.nlm.nih.gov/pubmed/19155493?dopt=Abstracty FULLTEXT
8564 8u https://lup.lub.lu.se/record/1289490
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:118188487
8564 8u https://doi.org/10.4049/jimmunol.182.3.1460

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