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OGRDB : a reference...
OGRDB : a reference database of inferred immune receptor genes
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- Lees, William (författare)
- Birkbeck, University of London
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- Busse, Christian E. (författare)
- German Cancer Research Centre
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- Corcoran, Martin (författare)
- Karolinska Institutet
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- Ohlin, Mats (författare)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
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- Scheepers, Cathrine (författare)
- National Institute for Communicable Diseases,University of the Witwatersrand
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- Matsen, Frederick A. (författare)
- Fred Hutchinson Cancer Research Center
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- Yaari, Gur (författare)
- Bar-Ilan University
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- Watson, Corey T. (författare)
- University of Louisville
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- Collins, Andrew (författare)
- University of New South Wales
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- Shepherd, Adrian J. (författare)
- Birkbeck, University of London
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(creator_code:org_t)
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- 2019-09-30
- 2020
- Engelska.
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 1362-4962 .- 0305-1048. ; 48:D1, s. 964-970
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- High-throughput sequencing of the adaptive immune receptor repertoire (AIRR-seq) is providing unprecedented insights into the immune response to disease and into the development of immune disorders. The accurate interpretation of AIRR-seq data depends on the existence of comprehensive germline gene reference sets. Current sets are known to be incomplete and unrepresentative of the degree of polymorphism and diversity in human and animal populations. A key issue is the complexity of the genomic regions in which they lie, which, because of the presence of multiple repeats, insertions and deletions, have not proved tractable with short-read whole genome sequencing. Recently, tools and methods for inferring such gene sequences from AIRR-seq datasets have become available, and a community approach has been developed for the expert review and publication of such inferences. Here, we present OGRDB, the Open Germline Receptor Database (https://ogrdb.airr-community.org), a public resource for the submission, review and publication of previously unknown receptor germline sequences together with supporting evidence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lees, William
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Busse, Christian ...
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Corcoran, Martin
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Ohlin, Mats
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Scheepers, Cathr ...
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Matsen, Frederic ...
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visa fler...
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Yaari, Gur
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Watson, Corey T.
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Collins, Andrew
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Shepherd, Adrian ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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Nucleic Acids Re ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet