Sökning: onr:"swepub:oai:lup.lub.lu.se:5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a" >
Thrombocytopenia an...
-
Anthon, Carl ThomasCopenhagen University Hospital
(författare)
Thrombocytopenia and platelet transfusions in ICU patients : an international inception cohort study (PLOT-ICU)
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a
-
https://lup.lub.lu.se/record/5ad84c4d-9a8b-4be8-bf10-bdabcc91a10aURI
-
https://doi.org/10.1007/s00134-023-07225-2DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
PURPOSE: Thrombocytopenia (platelet count < 150 × 10 9/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. METHODS: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.RESULTS: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).CONCLUSION: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Pène, Frédéric
(författare)
-
Perner, Anders
(författare)
-
Barratt-Due, AndreasOslo university hospital
(författare)
-
Chawla, SanjayMemorial Sloan-Kettering Cancer Center
(författare)
-
Kander, ThomasLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-tkn
(författare)
-
Hästbacka, Johanna
(författare)
-
Andreasen, Jo BøndingAalborg University Hospital
(författare)
-
Péju, Edwige
(författare)
-
Nielsen, Lene BjerregaardOdense University Hospital
(författare)
-
Hvas, Christine LodbergAarhus University Hospital
(författare)
-
Dufranc, Etienne
(författare)
-
Canet, Emmanuel
(författare)
-
Lundqvist, Linda
(författare)
-
Wright, Christopher John
(författare)
-
Voiriot, GuillaumeAssistance Publique des Hôpitaux de Paris
(författare)
-
Clausen, Niels ErikstrupBispebjerg Hospital
(författare)
-
Lorentzen, Kristian
(författare)
-
Kvåle, ReidarHaukeland University Hospital
(författare)
-
Hildebrandt, Thomas
(författare)
-
Holten, Aleksander RyghOslo university hospital
(författare)
-
Strand, KristianStavanger University Hospital
(författare)
-
Tzalavras, AsteriosUniversity Hospital Essen
(författare)
-
Bestle, Morten Heiberg
(författare)
-
Klepstad, Pål
(författare)
-
Fernandez, SaraUniversity of Barcelona
(författare)
-
Vimpere, Damien
(författare)
-
Paulino, CarolinaNOVA University Lisbon
(författare)
-
Costa, Carolina
(författare)
-
Bådstøløkken, Per Martin
(författare)
-
Miranda, TeresaCentro Hospitalar de Lisboa Ocidental (CHLO)
(författare)
-
Russell, LeneCopenhagen University Hospital
(författare)
-
Copenhagen University HospitalOslo university hospital
(creator_code:org_t)
-
PLOT-ICU Investigators and the Nine-I Study Group
Sammanhörande titlar
-
Ingår i:Intensive Care Medicine49:11, s. 1327-13380342-4642
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Anthon, Carl Tho ...
-
Pène, Frédéric
-
Perner, Anders
-
Barratt-Due, And ...
-
Chawla, Sanjay
-
Kander, Thomas
-
visa fler...
-
Hästbacka, Johan ...
-
Andreasen, Jo Bø ...
-
Péju, Edwige
-
Nielsen, Lene Bj ...
-
Hvas, Christine ...
-
Dufranc, Etienne
-
Canet, Emmanuel
-
Lundqvist, Linda
-
Wright, Christop ...
-
Voiriot, Guillau ...
-
Clausen, Niels E ...
-
Lorentzen, Krist ...
-
Kvåle, Reidar
-
Hildebrandt, Tho ...
-
Holten, Aleksand ...
-
Strand, Kristian
-
Tzalavras, Aster ...
-
Bestle, Morten H ...
-
Klepstad, Pål
-
Fernandez, Sara
-
Vimpere, Damien
-
Paulino, Carolin ...
-
Costa, Carolina
-
Bådstøløkken, Pe ...
-
Miranda, Teresa
-
Russell, Lene
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Anestesi och int ...
- Artiklar i publikationen
-
Intensive Care M ...
- Av lärosätet
-
Lunds universitet