Sökning: onr:"swepub:oai:lup.lub.lu.se:5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a" > Thrombocytopenia an...
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000 | 05471naa a2200661 4500 | |
001 | oai:lup.lub.lu.se:5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a | |
003 | SwePub | |
008 | 231015s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a2 URI |
024 | 7 | a https://doi.org/10.1007/s00134-023-07225-22 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Anthon, Carl Thomasu Copenhagen University Hospital4 aut |
245 | 1 0 | a Thrombocytopenia and platelet transfusions in ICU patients : an international inception cohort study (PLOT-ICU) |
264 | 1 | c 2023 |
520 | a PURPOSE: Thrombocytopenia (platelet count < 150 × 10 9/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. METHODS: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.RESULTS: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).CONCLUSION: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
700 | 1 | a Pène, Frédéric4 aut |
700 | 1 | a Perner, Anders4 aut |
700 | 1 | a Barratt-Due, Andreasu Oslo university hospital4 aut |
700 | 1 | a Chawla, Sanjayu Memorial Sloan-Kettering Cancer Center4 aut |
700 | 1 | a Kander, Thomasu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-tkn |
700 | 1 | a Hästbacka, Johanna4 aut |
700 | 1 | a Andreasen, Jo Bøndingu Aalborg University Hospital4 aut |
700 | 1 | a Péju, Edwige4 aut |
700 | 1 | a Nielsen, Lene Bjerregaardu Odense University Hospital4 aut |
700 | 1 | a Hvas, Christine Lodbergu Aarhus University Hospital4 aut |
700 | 1 | a Dufranc, Etienne4 aut |
700 | 1 | a Canet, Emmanuel4 aut |
700 | 1 | a Lundqvist, Linda4 aut |
700 | 1 | a Wright, Christopher John4 aut |
700 | 1 | a Voiriot, Guillaumeu Assistance Publique des Hôpitaux de Paris4 aut |
700 | 1 | a Clausen, Niels Erikstrupu Bispebjerg Hospital4 aut |
700 | 1 | a Lorentzen, Kristian4 aut |
700 | 1 | a Kvåle, Reidaru Haukeland University Hospital4 aut |
700 | 1 | a Hildebrandt, Thomas4 aut |
700 | 1 | a Holten, Aleksander Ryghu Oslo university hospital4 aut |
700 | 1 | a Strand, Kristianu Stavanger University Hospital4 aut |
700 | 1 | a Tzalavras, Asteriosu University Hospital Essen4 aut |
700 | 1 | a Bestle, Morten Heiberg4 aut |
700 | 1 | a Klepstad, Pål4 aut |
700 | 1 | a Fernandez, Sarau University of Barcelona4 aut |
700 | 1 | a Vimpere, Damien4 aut |
700 | 1 | a Paulino, Carolinau NOVA University Lisbon4 aut |
700 | 1 | a Costa, Carolina4 aut |
700 | 1 | a Bådstøløkken, Per Martin4 aut |
700 | 1 | a Miranda, Teresau Centro Hospitalar de Lisboa Ocidental (CHLO)4 aut |
700 | 1 | a Russell, Leneu Copenhagen University Hospital4 aut |
710 | 2 | a Copenhagen University Hospitalb Oslo university hospital4 org |
710 | 2 | a PLOT-ICU Investigators and the Nine-I Study Group |
773 | 0 | t Intensive Care Medicineg 49:11, s. 1327-1338q 49:11<1327-1338x 0342-4642 |
856 | 4 | u http://dx.doi.org/10.1007/s00134-023-07225-2x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/5ad84c4d-9a8b-4be8-bf10-bdabcc91a10a |
856 | 4 8 | u https://doi.org/10.1007/s00134-023-07225-2 |
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