Sökning: onr:"swepub:oai:lup.lub.lu.se:5b4a5259-e6ed-4a7b-a565-3e9ec3140b57" >
Cartilage oligomeri...
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.
-
Svensson, Liz (författare)
-
- Aszodi, Attila (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Heinegård, Dick (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
visa fler...
-
Hunziker, Ernst B (författare)
-
Reinholt, Finn P (författare)
-
Fässler, Reinhard (författare)
-
- Oldberg, Åke (författare)
- Lund University,Lunds universitet,Åke Oldbergs forskargrupp,Forskargrupper vid Lunds universitet,Åke Oldberg´s group,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
- 2002
- 2002
- Engelska.
-
Ingår i: Molecular and Cellular Biology. - 0270-7306. ; 22:12, s. 4366-4371
- Relaterad länk:
-
https://portal.resea... (primary) (free)
-
visa fler...
-
http://www.ncbi.nlm.... (free)
-
http://mcb.asm.org/c... (free)
-
http://dx.doi.org/10... (free)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Cartilage oligomeric matrix protein (COMP) belongs to the thrombospondin family and is a homopentamer primarily expressed in cartilage. Mutations in the COMP gene result in the autosomal dominant chondrodysplasias pseudoachondroplasia (PSACH) and some types of multiple epiphyseal dysplasia (MED), which are characterized by mild to severe short-limb dwarfism and early-onset osteoarthritis. We have generated COMP-null mice to study the role of COMP in vivo. These mice show no anatomical, histological, or ultrastructural abnormalities and show none of the clinical signs of PSACH or MED. Northern blot analysis and immunohistochemical analysis of cartilage indicate that the lack of COMP is not compensated for by any other member of the thrombospondin family. The results also show that the phenotype in PSACH/MED cartilage disorders is not caused by the reduced amount of COMP.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Extracellular Matrix Proteins : metabolism
- Glycoproteins : deficiency
- Female
- Glycoproteins : genetics
- Glycoproteins : metabolism
- Male
- Mice
- Inbred Strains
- Mutant Strains
- Reference Values
- Skeleton
- Reverse Transcriptase Polymerase Chain Reaction
- Support
- Non-U.S. Gov't
- Tibia : growth & development
- Tibia : anatomy & histology
- Extracellular Matrix Proteins : genetics
- Extracellular Matrix Proteins : deficiency
- Cartilage : ultrastructure
- Cartilage : growth & development
- Cartilage : anatomy & histology
- Animal
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas