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Polycyclic aromatic...
Polycyclic aromatic hydrocarbon (PAH) exposure during pregnancy and child anthropometry from birth to 10 years of age : Sex-specific evidence from a cohort study in rural Bangladesh
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- Moshfiqur Rahman, Syed (författare)
- Uppsala universitet,Uppsala University,International Centre for Diarrhoeal Disease Research, Bangladesh,Internationell barnhälsa och nutrition,Bangladesh Icddr B, Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh.
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- Malin Igra, Annachiara (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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- Essig, Julie Y (författare)
- Lund University,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, Lund, Sweden.
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- Ekström, Eva-Charlotte (författare)
- Uppsala universitet,Uppsala University,Internationell barnhälsa och nutrition
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- Dreij, Kristian (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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- Trask, Mercedes (författare)
- Uppsala universitet,Uppsala University,Institutionen för kvinnors och barns hälsa
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- Lindh, Christian (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, Lund, Sweden.
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- Arifeen, Shams El (författare)
- International Centre for Diarrhoeal Disease Research, Bangladesh,Bangladesh Icddr B, Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh.
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- Rahman, Anisur (författare)
- International Centre for Diarrhoeal Disease Research, Bangladesh,Bangladesh Icddr B, Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh.
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- Krais, Annette M (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, Lund, Sweden.
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- Kippler, Maria (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska 8 s.
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Ingår i: Environmental Research. - : Elsevier BV. - 1096-0953 .- 0013-9351. ; 227
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Polycyclic aromatic hydrocarbons (PAHs) have endocrine disrupting properties and they cross the placental barrier, but studies on gestational exposure and child anthropometry are inconclusive. We aimed to elucidate the impact of early gestational PAH exposure on anthropometry from birth to 10 years of age in 1295 mother-child pairs from a nested sub-cohort of the MINIMat trial in Bangladesh. Several PAH metabolites [1-hydroxyphenanthrene (1-OH-Phe), Σ2-,3-hydroxyphenanthrene (Σ2-,3-OH-Phe), 4-hydroxyphenanthrene (4-OH-Phe), 1-hydroxypyrene (1-OH-Pyr), Σ2-,3-hydroxyfluorene (Σ2-,3-OH-Flu)] were quantified in spot urine collected around gestational week 8 using LC-MS/MS. Child weight and height were measured at 19 occasions from birth to 10 years. Multivariable-adjusted regression models were used to assess associations of maternal PAH metabolites (log 2-transformed) with child anthropometry. The median concentration of 1-OH-Phe, Σ2-,3-OH-Phe, 4-OH-Phe, 1-OH-Pyr and Σ2-,3-OH-Flu was 1.5, 1.9, 0.14, 2.5, and 2.0 ng/mL, respectively. All maternal urinary PAH metabolites were positively associated with newborn weight and length and all associations were more pronounced in boys than in girls (p interaction for all <0.14). In boys, the strongest associations were observed with Σ2-,3-OH-Phe and Σ2-,3-OH-Flu for which each doubling increased mean birth weight by 41 g (95% CI: 13; 69 and 12; 70) and length by 0.23 cm (0.075; 0.39) and 0.21 cm (0.045; 0.37), respectively. Maternal urinary PAH metabolites were not associated with child anthropometry at 10 years. In longitudinal analysis, however, maternal urinary PAH metabolites were positively associated with boys' weight-for-age (WAZ) and height-for-age Z-scores (HAZ) from birth to 10 years, but only the association of 4-OH-Phe with HAZ was significant (B: 0.080 Z-scores; 95% CI 0.013, 0.15). No associations were observed with girls' WAZ or HAZ. In conclusion, gestational PAH exposure was positively associated with fetal and early childhood growth, especially in boys. Further studies are needed to confirm causality and to explore long-term health effects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Anthropometry
- Birth size
- Birth weight
- Growth
- Polycyclic aromatic hydrocarbons
- Pre-pubertal age
- Anthropometry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Moshfiqur Rahman ...
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Malin Igra, Anna ...
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Essig, Julie Y
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Ekström, Eva-Cha ...
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Dreij, Kristian
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Trask, Mercedes
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Lindh, Christian
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Arifeen, Shams E ...
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Rahman, Anisur
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Krais, Annette M
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Kippler, Maria
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