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Sökning: onr:"swepub:oai:lup.lub.lu.se:5e300689-7165-4ced-a21d-61989db7823b" > Somatic disease in ...

  • Pedersen, CamillaDanish Cancer Society (författare)

Somatic disease in survivors of childhood malignant bone tumors in the nordic countries

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-09-07
  • MDPI AG,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:5e300689-7165-4ced-a21d-61989db7823b
  • https://lup.lub.lu.se/record/5e300689-7165-4ced-a21d-61989db7823bURI
  • https://doi.org/10.3390/cancers13184505DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finland, Iceland, and Sweden during 1943–2008, were followed in the national hospital registers. Overall rates of hospital contacts for any somatic disease and for 12 main diagnostic groups and 120 specific disease categories were compared with those in a matched comparison cohort (n = 3049) randomly selected from the national population registers. The rate of hospital contact for any somatic disease was 80% higher in survivors of malignant bone tumors than in comparisons and remained elevated up to 30 years after diagnosis. The rate of hospital contacts was higher after Ewing sarcoma (rate ratio (RR) 2.24; 95% confidence interval (CI) 1.76–2.85) than after osteosarcoma (RR 1.67; 95% CI 1.41–1.98). Elevated rates were observed for 11 main diagnostic groups, including infections, second malignant neoplasms, and diseases of the skin, bones, and circulatory, digestive, endocrine, and urinary systems. Survivors of malignant bone tumors in childhood are at increased risk of somatic diseases many years after diagnosis. This comprehensive study contributes new insight into the risk of late effects in survivors of osteosarcoma and Ewing sarcoma, which is an essential basis for optimal patient counseling and follow-up care.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rechnitzer, CatherineCopenhagen University Hospital (författare)
  • Andersen, Elisabeth Anne WrefordDanish Cancer Society (författare)
  • Kenborg, LineDanish Cancer Society (författare)
  • Norsker, Filippa NyboeDanish Cancer Society (författare)
  • Bautz, AndreaDanish Cancer Society (författare)
  • Baad-Hansen, ThomasAarhus University Hospital (författare)
  • Tryggvadottir, LaufeyIcelandic Cancer Registry (författare)
  • Madanat-Harjuoja, Laura MariaFinnish Cancer Registry (författare)
  • Holmqvist, Anna SällforsLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)med-as- (författare)
  • Hjorth, LarsLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)pedi-lhj (författare)
  • Hasle, HenrikAarhus University Hospital (författare)
  • Winther, Jeanette FalckDanish Cancer Society,Aarhus University Hospital (författare)
  • Danish Cancer SocietyCopenhagen University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancers: MDPI AG13:182072-6694

Internetlänk

Hitta via bibliotek

  • Cancers (Sök värdpublikationen i LIBRIS)

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