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Fabrication of a si...
Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration
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- Chen, Peilin (författare)
- University of Western Australia, Perth
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- Wu, Zhigang (författare)
- University of Western Australia, Perth
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- Leung, Alex (författare)
- University of Western Australia, Perth
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- Chen, Xiaobo (författare)
- RMIT University
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- Landao-Bassonga, Euphemie (författare)
- University of Western Australia, Perth
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- Gao, Junjie (författare)
- University of Western Australia, Perth
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- Chen, Lianzhi (författare)
- University of Western Australia, Perth
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- Zheng, Monica (författare)
- University of Notre Dame Australia
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- Yao, Felix (författare)
- University of Western Australia, Perth
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- Yang, Hong (författare)
- University of Western Australia, Perth
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- Lidgren, Lars (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Allan, Brent (författare)
- St John of God Medical Centre
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- Liu, Yinong (författare)
- University of Western Australia, Perth
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- Wang, Tao (författare)
- University of Western Australia, Perth
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- Zheng, Minghao (författare)
- University of Western Australia, Perth
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Biomedical materials. - 1748-6041. ; 13:6
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering. The optimized AgNP-coated collagen membrane exhibited excellent anti-bacterial effects against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) with limited cellular toxicity. It also displayed effective anti-inflammatory effects by reducing the expression and release of inflammatory cytokines including IL-6 and TNF-alpha. Additionally, AgNP-coated collagen membranes were able to induce osteogenic differentiation of mesenchymal stem cells that guide bone regeneration. These findings demonstrate the potential application of AgNP-coated collagen membranes to prevent infection after bone graft introduction in alveolar ridge reconstruction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Chen, Peilin
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Wu, Zhigang
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Leung, Alex
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Chen, Xiaobo
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Landao-Bassonga, ...
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Gao, Junjie
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visa fler...
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Chen, Lianzhi
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Zheng, Monica
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Yao, Felix
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Yang, Hong
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Lidgren, Lars
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Allan, Brent
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Liu, Yinong
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Wang, Tao
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Zheng, Minghao
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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Biomedical mater ...
- Av lärosätet
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Lunds universitet