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The role of glia in...
The role of glia in Parkinson's disease : Emerging concepts and therapeutic applications
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- Kuter, Katarzyna Z. (författare)
- Institute of Pharmacology of the Polish Academy of Sciences
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- Cenci, M. Angela (författare)
- Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups
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- Carta, Anna R. (författare)
- University of Cagliari
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Björklund, Anders (redaktör/utgivare)
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Cenci, M. Angela (redaktör/utgivare)
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska 38 s.
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Ingår i: Recent Advances in Parkinson's Disease. - : Elsevier. - 0079-6123 .- 1875-7855. - 9780444642608 ; 252, s. 131-168
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare histopathological and molecular findings from experimental models of PD and human studies. We moreover discuss the important role played by astrocytes in compensatory adaptations taking place during presymptomatic disease stages. We finally describe examples of potential therapeutic applications stemming from an increased understanding of the important roles of glia in PD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Astrocytes
- Compensation
- Dyskinesia
- Energy metabolism
- Grafting
- Inflammation
- Levodopa
- Microglia
- Pharmacology
- α-Synuclein
Publikations- och innehållstyp
- kap (ämneskategori)
- ref (ämneskategori)
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