Sökning: onr:"swepub:oai:lup.lub.lu.se:6004cd35-dbad-460d-8671-7a15ba18b814" >
C-Reactive Protein ...
C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
-
- Enocsson, Helena (författare)
- Linköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten
-
- Gullstrand, Birgitta (författare)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Dept Clin Sci Lund, Div Rheumatol, Lund, Sweden.
-
- Eloranta, Maija-Leena (författare)
- Uppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden
-
visa fler...
-
- Wetterö, Jonas (författare)
- Linköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten
-
- Leonard, Dag, 1975- (författare)
- Uppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden
-
- Rönnblom, Lars (författare)
- Uppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden
-
- Bengtsson, Anders A. (författare)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Dept Clin Sci Lund, Div Rheumatol, Lund, Sweden.
-
- Sjöwall, Christopher (författare)
- Linköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
-
visa färre...
-
Linköping University Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden (creator_code:org_t)
- 2021-01-28
- 2021
- Engelska.
-
Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 11
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://www.frontier...
-
https://doi.org/10.3...
-
https://uu.diva-port... (primary) (Raw object)
-
https://liu.diva-por... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives: Patients with systemic lupus erythematosus (SLE) often display modest elevations of C-reactive protein (CRP) despite raised disease activity and increased interleukin (IL-) 6. We asked to what extent IL-6 levels, the CRP polymorphism rs1205, and the type I interferon (IFN) gene signature affects the basal CRP levels in patients with SLE during a quiescent phase of the disease. Methods: CRP and IL-6 were analyzed in plasma from 57 patients meeting established classification criteria for SLE. The CRP polymorphism rs1205 was assessed and gene expression analyzed including four type I IFN-regulated genes (IGS). Results: CRP was increased in patients with detectable IL-6 levels (p=0.001) and decreased among IGS-positive subjects (p=0.033). A multiple linear regression model revealed IL-6 to have a positive association with CRP levels, whereas both IGS-positivity and CRP genotype (rs1205) AA/GA were negatively associated with CRP-levels. Conclusion: Our data offer an explanation to the modest CRP levels seen in viral infections and IFN-α driven autoimmunity and corroborate prior observations showing an IFN-α dependent downregulation of CRP. The latter observation, together with the fact that the CRP-lowering polymorphism rs1205 is overrepresented in human SLE, could explain low basal CRP and inadequate CRP-responses among patients with active SLE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- biomarker
- C-reactive protein
- gene variants
- inflammation
- interferon
- pentraxins
- systemic lupus erythematosus
- type I interferons
- C-reactive protein
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas