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Molecular character...
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Aaltonen, Kristina E.Lund University,Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,Forskargrupper vid Lunds universitet,The Liquid Biopsy and Tumor Progression in Breast Cancer,Lund University Research Groups
(författare)
Molecular characterization of circulating tumor cells from patients with metastatic breast cancer reflects evolutionary changes in gene expression under the pressure of systemic therapy
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-04-20
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Impact Journals, LLC,2017
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22 s.
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LIBRIS-ID:oai:lup.lub.lu.se:608e05cb-0815-4aec-99dd-964ccf45c929
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https://lup.lub.lu.se/record/608e05cb-0815-4aec-99dd-964ccf45c929URI
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https://doi.org/10.18632/oncotarget.17271DOI
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Språk:engelska
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Sammanfattning på:engelska
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Resistance to systemic therapy is a major problem in metastatic breast cancer (MBC) that can be explained by initial tumor heterogeneity as well as by evolutionary changes during therapy and tumor progression. Circulating tumor cells (CTCs) detected in a liquid biopsy can be sampled and characterized repeatedly during therapy in order to monitor treatment response and disease progression. Our aim was to investigate how CTC derived gene expression of treatment predictive markers (ESR1/HER2) and other cancer associated markers changed in patient blood samples during six months of first-line systemic treatment for MBC. CTCs from 36 patients were enriched using CellSearch (Janssen Diagnostics) and AdnaTest (QIAGEN) before gene expression analysis was performed with a customized gene panel (TATAA Biocenter). Our results show that antibodies against HER2 and EGFR were valuable to isolate CTCs unidentified by CellSearch and possibly lacking EpCAM expression. Evaluation of patients with clinically different breast cancer subgroups demonstrated that gene expression of treatment predictive markers changed over time. This change was especially prominent for HER2 expression. In conclusion, we found that changed gene expression during first-line systemic therapy for MBC could be a possible explanation for treatment resistance. Characterization of CTCs at several time-points during therapy could be informative for treatment selection.
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Novosadová, VendulaAcademy of Sciences of the Czech Republic
(författare)
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Bendahl, Pär OlaLund University,Lunds universitet,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,Personalized Breast Cancer Treatment,Lund University Research Groups,The Liquid Biopsy and Tumor Progression in Breast Cancer(Swepub:lu)onk-pbe
(författare)
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Graffman, CeciliaSkåne University Hospital(Swepub:lu)onk-cf8
(författare)
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Larsson, Anna MariaLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)onk-aol
(författare)
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Rydén, LisaLund University,Lunds universitet,Bröstcancerkirurgi,Forskargrupper vid Lunds universitet,Breast Cancer Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pat-lry
(författare)
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The Liquid Biopsy och Tumörprogression i BröstcancerForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Oncotarget: Impact Journals, LLC8:28, s. 45544-455651949-2553
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