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Clinical Correlates...
Clinical Correlates of Benefit From Radium-223 Therapy in Metastatic Castration Resistant Prostate Cancer
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- Alva, Ajjai (författare)
- University of Michigan
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- Nordquist, Luke (författare)
- Urology Cancer Center, Omaha
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- Daignault, Stephanie (författare)
- University of Michigan
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- George, Saby (författare)
- Roswell Park Cancer Institute
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- Ramos, Jorge (författare)
- Fred Hutchinson Cancer Research Center
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- Albany, Costantine (författare)
- Indiana University
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- Isharwal, Sudhir (författare)
- Urology Cancer Center, Omaha
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- McDonald, Matthew (författare)
- Urology Cancer Center, Omaha
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- Campbell, Gregory (författare)
- University of Michigan
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- Danchaivijitr, Pongwut (författare)
- Roswell Park Cancer Institute
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- Yentz, Sarah (författare)
- University of Michigan
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- Anand, Aseem (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
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- Yu, Evan Y. (författare)
- Fred Hutchinson Cancer Research Center
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(creator_code:org_t)
- 2016-12-19
- 2017
- Engelska 10 s.
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Ingår i: Prostate. - : Wiley. - 0270-4137. ; 77:5, s. 479-488
- Relaterad länk:
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http://dx.doi.org/10...
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http://deepblue.lib....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: We sought to identify potential clinical variables associated with outcomes after radium-223 therapy in routine practice. METHODS: Consecutive non-trial mCRPC patients who received ≥1 dose of radium dichloride-223 at four academic and one community urology-specific cancer centers from May 2013 to June 2014 were retrospectively identified. Association of baseline and on-therapy clinical variables with number of radium doses received and clinical outcomes including overall survival were analyzed using chi-square statistics, cox proportional hazards, and Kaplan–Meier methods. Bone Scan Index (BSI) was derived from available bone scans using EXINI software. RESULTS: One hundred and forty-five patients were included. Radium-223 was administered for six cycles in 74 patients (51%). One-year survival in this heavily pre-treated population was 64% (95%CI: 54–73%). In univariate and multivariate analysis, survival was highly associated with receiving all six doses of Radium-223. Receipt of six doses was associated with ECOG PS of 0–1, lower baseline PSA & pain level, no prior abiraterone/enzalutamide, <5 BSI value, and normal alkaline phosphatase. In patients who reported baseline pain (n = 72), pain declined in 51% after one dose and increased in 7%. PSA declined ≥50% in 16% (18/110). Alkaline phosphatase declined ≥25% in 48% (33/69) and ≥50% in 16/69 patients. BSI declined in 17 (68%) of the 25 patients who had bone scan available at treatment follow-up. Grade ≥3 neutropenia, anemia, and thrombocytopenia occurred in 4% (n = 114), 4% (n = 125), and 5% (n = 123), respectively. CONCLUSIONS: Patients earlier in their disease course with <5 BSI, low pain score, and good ECOG performance status are optimal candidates for radium-223. Radium-223 therapy is well tolerated with most patients reporting declines in pain scores and BSI. Prostate 77:479–488, 2017.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Bone Scan Index
- outcomes
- variables
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Prostate
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Till lärosätets databas
- Av författaren/redakt...
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Alva, Ajjai
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Nordquist, Luke
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Daignault, Steph ...
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George, Saby
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Ramos, Jorge
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Albany, Costanti ...
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Isharwal, Sudhir
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McDonald, Matthe ...
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Campbell, Gregor ...
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Danchaivijitr, P ...
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Yentz, Sarah
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Anand, Aseem
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Yu, Evan Y.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Prostate
- Av lärosätet
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Lunds universitet