onr:"swepub:oai:lup.lub.lu.se:63ff9ead-1a5b-40ca-8b07-08917af2ffe5"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04750naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:63ff9ead-1a5b-40ca-8b07-08917af2ffe5 | |
| 003 | SwePub | |
| 008 | 190524s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/63ff9ead-1a5b-40ca-8b07-08917af2ffe52 URI |
| 024 | 7 | a https://doi.org/10.1155/2019/27140492 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Cataldo Buscunan, Rodrigou Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Endokrin Celldifferentiering,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Endocrine Cell Differentiation and Function,Pontifical Catholic University of Chile4 aut0 (Swepub:lu)lu3583ca |
| 245 | 1 0 | a Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women |
| 264 | 1 | b Hindawi Limited,c 2019 |
| 300 | a 11 s. | |
| 520 | a Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir. 5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism. However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a) to assess the association between platelet 5HT levels and plasma concentration of nonesterified fatty acids (NEFAs) and some adipokines including leptin and its soluble leptin receptor (sOb-R), (b) to assess the association between platelet 5HT levels and anthropometric traits and indexes of insulin secretion/sensitivity derived from oral glucose tolerance test (OGTT), and (c) to evaluate changes in platelet 5HT levels in response to OGTT. In a cross-sectional study, 59 normoglycemic women underwent a standard 2-hour OGTT. Plasma leptin, sOb-R, total and high molecular weight adiponectin, TNFα, and MCP1 were determined by immunoassays. Platelet 5HT levels and NEFAs were measured before and after OGTT. The free leptin index was calculated from leptin and sOb-R measurements. Insulin sensitivity indexes derived from OGTT (HOMA-S and Matsuda ISICOMP) and plasma NEFAs (Adipose-IR, Revised QUICKI) were also calculated. Our data show that among metabolic traits, platelet 5HT levels were associated with plasma sOb-R (, , corrected ). Platelet 5HT levels were reduced in response to OGTT ( vs platelets, ). In conclusion, platelet 5HT levels are positively associated with plasma sOb-R concentrations and reduced in response to glucose intake possibly indicating a role of peripheral 5HT in leptin-mediated appetite regulation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
| 700 | 1 | a Suazo, Joséu University of Chile4 aut |
| 700 | 1 | a Olmos, Pablou Pontifical Catholic University of Chile4 aut |
| 700 | 1 | a Bravo, Carolinau Pontifical Catholic University of Chile4 aut |
| 700 | 1 | a Galgani, José E.u Pontifical Catholic University of Chile4 aut |
| 700 | 1 | a Fex, Malinu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Diabetes - molekylär metabolism,Department of Clinical Sciences, Malmö,Faculty of Medicine,Celiac Disease and Diabetes Unit,Lund University Research Groups,Diabetes - Molecular Metabolism4 aut0 (Swepub:lu)medk-mf0 |
| 700 | 1 | a Martínez, J. Alfredou Carlos III Health Institute,University of Navarra4 aut |
| 700 | 1 | a Santos, José L.u Pontifical Catholic University of Chile4 aut |
| 710 | 2 | a -lup-obsoleteb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Diabetes Researchd : Hindawi Limitedg 2019q 2019x 2314-6753x 2314-6745 |
| 856 | 4 | u http://dx.doi.org/10.1155/2019/2714049x freey FULLTEXT |
| 856 | 4 | u https://downloads.hindawi.com/journals/jdr/2019/2714049.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/63ff9ead-1a5b-40ca-8b07-08917af2ffe5 |
| 856 | 4 8 | u https://doi.org/10.1155/2019/2714049 |
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