Sökning: onr:"swepub:oai:lup.lub.lu.se:649deff4-7b3a-422b-8dbe-c574de12ea9d" > Targeting MYC induc...
Fältnamn | Indikatorer | Metadata |
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001 | oai:lup.lub.lu.se:649deff4-7b3a-422b-8dbe-c574de12ea9d | |
003 | SwePub | |
008 | 240312s2024 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-523864 | |
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024 | 7 | a https://lup.lub.lu.se/record/649deff4-7b3a-422b-8dbe-c574de12ea9d2 URI |
024 | 7 | a https://doi.org/10.1073/pnas.23104791212 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5238642 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2383352552 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1551158112 URI |
040 | a (SwePub)lud (SwePub)uud (SwePub)kid (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Sainero-Alcolado, Lourdesu Karolinska Institutet,Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut |
245 | 1 0 | a Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma |
264 | 1 | b Proceedings of the National Academy of Sciences (PNAS),c 2024 |
520 | a Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC) tumorigenesis, manifested by accumulation of lipid droplets (LDs), organelles that have emerged as new hallmarks of cancer. Yet, regulation of their biogenesis is still poorly understood. Here, we demonstrate that MYC inhibition in ccRCC cells lacking the von Hippel Lindau (VHL) gene leads to increased triglyceride content potentiating LD formation in a glutamine-dependent manner. Importantly, the concurrent inhibition of MYC signaling and glutamine metabolism prevented LD accumulation and reduced tumor burden in vivo. Furthermore, we identified the hypoxia-inducible lipid droplet-associated protein (HILPDA) as the key driver for induction of MYC-driven LD accumulation and demonstrated that conversely, proliferation, LD formation, and tumor growth are impaired upon its downregulation. Finally, analysis of ccRCC tissue as well as healthy renal control samples postulated HILPDA as a specific ccRCC biomarker. Together, these results provide an attractive approach for development of alternative therapeutic interventions for the treatment of this type of renal cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
653 | a clear cell renal cell carcinoma | |
653 | a glutamine | |
653 | a HILPDA | |
653 | a lipid droplets | |
653 | a MYC | |
700 | 1 | a Garde-Lapido, Elisau Karolinska Institutet,Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut |
700 | 1 | a Snaebjörnsson, Marteinn Thoru Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg 69120, Germany4 aut |
700 | 1 | a Schoch, Sarahu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Njurcancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Kidney cancer research group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund 22100, Sweden4 aut0 (Swepub:lu)sa4445sc |
700 | 1 | a Stevens, Ireneu Karolinska Institutet,Karolinska Institute,Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17165, Sweden4 aut |
700 | 1 | a Ruiz-Pérez, María Victoriau Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut |
700 | 1 | a Dyrager, Christineu Uppsala universitet,Uppsala University,Organisk kemi4 aut0 (Swepub:uu)chrdy437 |
700 | 1 | a Pelechano, Vicentu Karolinska Institutet,Karolinska Institute,Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17165, Sweden4 aut |
700 | 1 | a Axelson, Håkanu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Njurcancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Kidney cancer research group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund 22100, Sweden4 aut0 (Swepub:lu)molm-hax |
700 | 1 | a Schulze, Almutu Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg 69120, Germany4 aut |
700 | 1 | a Arsenian-Henriksson, Marieu Karolinska Institutet,Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut |
710 | 2 | a Karolinska Instituteb Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciences (PNAS)g 121:7, s. 2310479121-2310479121q 121:7<2310479121-2310479121x 1091-6490x 0027-8424 |
856 | 4 | u http://dx.doi.org/10.1073/pnas.2310479121x freey FULLTEXT |
856 | 4 | u https://doi.org/10.1073/pnas.2310479121y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1840526/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://lup.lub.lu.se/record/649deff4-7b3a-422b-8dbe-c574de12ea9d |
856 | 4 8 | u https://doi.org/10.1073/pnas.2310479121 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523864 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:238335255 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:155115811 |
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