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Prospective validat...
Prospective validation of microseminoprotein-β added to the 4Kscore in predicting high-grade prostate cancer in an international multicentre cohort
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- Lonergan, Peter E. (författare)
- UCSF Helen Diller Family Comprehensive Cancer Center,University of California, San Francisco
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- Vertosick, Emily A. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Assel, Melissa (författare)
- Memorial Sloan-Kettering Cancer Center
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- Sjoberg, Daniel D. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Haese, Alexander (författare)
- University Medical Center Hamburg-Eppendorf
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- Graefen, Markus (författare)
- University Medical Center Hamburg-Eppendorf
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- Boorjian, Stephen A. (författare)
- Mayo Clinic Minnesota
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- Klee, George G. (författare)
- Mayo Clinic Minnesota
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- Cooperberg, Matthew R. (författare)
- University of California, San Francisco,UCSF Helen Diller Family Comprehensive Cancer Center
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- Pettersson, Kim (författare)
- University of Turku
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- Routila, Erica (författare)
- University of Turku
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- Vickers, Andrew J. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Lilja, Hans (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Clinical Chemistry, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Memorial Sloan-Kettering Cancer Center
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(creator_code:org_t)
- 2020-12-28
- 2021
- Engelska 7 s.
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Ingår i: BJU International. - : Wiley. - 1464-4096 .- 1464-410X. ; 128:2, s. 218-224
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: To prospectively evaluate the performance of a pre-specified statistical model based on four kallikrein markers in blood (total prostate-specific antigen [PSA], free PSA, intact PSA, and human kallikrein-related peptidase 2), commercially available as the 4Kscore, in predicting Gleason Grade Group (GG) ≥2 prostate cancer at biopsy in an international multicentre study at three academic medical centres, and whether microseminoprotein-β (MSP) adds predictive value. Patients and Methods: A total of 984 men were prospectively enrolled at three academic centres. The primary outcome was GG ≥2 on prostate biopsy. Three pre-specified statistical models were used: a base model including PSA, age, digital rectal examination and prior negative biopsy; a model that added free PSA to the base model; and the 4Kscore. Results: A total of 947 men were included in the final analysis and 273 (29%) had GG ≥2 on prostate biopsy. The base model area under the receiver operating characteristic curve of 0.775 increased to 0.802 with the addition of free PSA, and to 0.824 for the 4Kscore. Adding MSP to the 4Kscore model yielded an increase (0.014–0.019) in discrimination. In decision-curve analysis of clinical utility, the 4Kscore showed a benefit starting at a 7.5% threshold. Conclusion: A prospective multicentre evaluation of a pre-specified model based on four kallikrein markers (4Kscore) with the addition of MSP improves the predictive discrimination for GG ≥2 prostate cancer on biopsy and could be used to inform biopsy decision-making.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- #PCSM
- #ProstateCancer
- #uroonc
- 4Kscore
- kallikreins
- microseminoprotein-β
- prostate biopsy
- Prostate-specific antigen
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- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Lonergan, Peter ...
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Vertosick, Emily ...
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Assel, Melissa
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Sjoberg, Daniel ...
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Haese, Alexander
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Graefen, Markus
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visa fler...
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Boorjian, Stephe ...
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Klee, George G.
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Cooperberg, Matt ...
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Pettersson, Kim
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Routila, Erica
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Vickers, Andrew ...
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Lilja, Hans
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visa färre...
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Lunds universitet