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Human adipogenesis ...
Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes
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- Broholm, Christa (författare)
- Copenhagen University Hospital
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- Olsson, Anders Henrik (författare)
- Copenhagen University Hospital
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- Perfilyev, Alexander (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
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- Gillberg, Linn (författare)
- Copenhagen University Hospital
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- Hansen, Ninna Schiøler (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Ali, Ashfaq (författare)
- Skåne University Hospital
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- Mortensen, Brynjulf (författare)
- Steno Diabetes Center Copenhagen
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- Ling, Charlotte (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
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- Vaag, Allan (författare)
- Copenhagen University Hospital,Steno Diabetes Center Copenhagen,University of Copenhagen
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(creator_code:org_t)
- Future Medicine Ltd, 2016
- 2016
- Engelska 17 s.
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Ingår i: Epigenomics. - : Future Medicine Ltd. - 1750-1911 .- 1750-192X. ; 8:12, s. 1601-1617
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Aim: To define the genomic distribution and function of DNA methylation changes during human adipogenesis. Methods: We isolated adipocyte-derived stem cells from 13 individuals and analyzed genome-wide DNA methylation and gene expression in cultured adipocyte-derived stem cells and mature adipocytes. Results: We observed altered DNA methylation of 11,947 CpG sites and altered expression of 11,830 transcripts after differentiation. De novo methylation was observed across all genomic elements. Co-existence of genes with both altered expression and DNA methylation was found in genes important for cell cycle and adipokine signaling. Conclusion: Human adipogenesis is associated with significant DNA methylation changes across the entire genome and may impact regulation of cell cycle and adipokine signaling.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- adipogenesis
- adiponectin
- DNA methylation
- epigenetics
- stem cells
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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