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Sökning: onr:"swepub:oai:lup.lub.lu.se:65db3efa-807a-4b5f-85ca-19d39051b1e0" > Absolute Risk Predi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003789naa a2200505 4500
001oai:lup.lub.lu.se:65db3efa-807a-4b5f-85ca-19d39051b1e0
003SwePub
008160404s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/32186412 URI
0247 a https://doi.org/10.1200/JCO.2012.41.89962 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Kovalchik, Stephanie A4 aut
2451 0a Absolute Risk Prediction of Second Primary Thyroid Cancer Among 5-Year Survivors of Childhood Cancer.
264 1c 2012
520 a PURPOSEWe developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors. PATIENTS AND METHODSWe used data from the Childhood Cancer Survivor Study (CCSS) and two nested case-control studies (Nordic CCSS; Late Effects Study Group). Model M1 included self-reported risk factors, model M2 added basic radiation and chemotherapy treatment information abstracted from medical records, and model M3 refined M2 by incorporating reconstructed radiation absorbed dose to the thyroid. All models were validated in an independent cohort of French childhood cancer survivors.ResultsM1 included birth year, initial cancer type, age at diagnosis, sex, and past thyroid nodule diagnosis. M2 added radiation (yes/no), radiation to the neck (yes/no), and alkylating agent (yes/no). Past thyroid nodule was consistently the strongest risk factor (M1 relative risk [RR ], 10.8; M2 RR, 6.8; M3 RR, 8.2). In the validation cohort, 20-year absolute risk predictions for second primary thyroid cancer ranged from 0.04% to 7.4% for M2. Expected events agreed well with observed events for each model, indicating good calibration. All models had good discriminatory ability (M1 area under the receiver operating characteristics curve [AUC ], 0.71; 95% CI, 0.64 to 0.77; M2 AUC, 0.80; 95% CI, 0.73 to 0.86; M3 AUC, 0.75; 95% CI, 0.69 to 0.82). CONCLUSIONWe developed and validated three absolute risk models for second primary thyroid cancer. Model M2, with basic prior treatment information, could be useful for monitoring thyroid cancer risk in childhood cancer survivors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Ronckers, Cécile M4 aut
7001 a Veiga, Lene H S4 aut
7001 a Sigurdson, Alice J4 aut
7001 a Inskip, Peter D4 aut
7001 a de Vathaire, Florent4 aut
7001 a Sklar, Charles A4 aut
7001 a Donaldson, Sarah S4 aut
7001 a Anderson, Haraldu Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-han
7001 a Bhatti, Parveen4 aut
7001 a Hammond, Sue4 aut
7001 a Leisenring, Wendy M4 aut
7001 a Mertens, Ann C4 aut
7001 a Smith, Susan A4 aut
7001 a Stovall, Marilyn4 aut
7001 a Tucker, Margaret A4 aut
7001 a Weathers, Rita E4 aut
7001 a Robison, Leslie L4 aut
7001 a Pfeiffer, Ruth M4 aut
7102 a Medicinsk onkologib Sektion I4 org
7730 t Journal of Clinical Oncologyx 1527-7755
8564 u http://www.ncbi.nlm.nih.gov/pubmed/23169509?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1200/JCO.2012.41.8996y FULLTEXT
8564 8u https://lup.lub.lu.se/record/3218641
8564 8u https://doi.org/10.1200/JCO.2012.41.8996

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