Sökning: onr:"swepub:oai:lup.lub.lu.se:6633b78e-bc58-4078-9a3b-b2b7731b9ad0" >
Stored blood transf...
Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage.
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:6633b78e-bc58-4078-9a3b-b2b7731b9ad0
-
https://lup.lub.lu.se/record/3915940URI
-
https://doi.org/10.1111/vox.12032DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
BACKGROUND AND OBJECTIVES: Transfusion of blood products in particular older products is associated with patient morbidity. Previously, we demonstrated a higher incidence of acute lung injury in lipopolysaccharide-treated sheep transfused with stored blood products. As transfusion following haemorrhage is more common, we aimed to determine whether a 'first hit' of isolated haemorrhage would precipitate similar detrimental effects following transfusion and also disrupt haemostasis. MATERIALS AND METHODS: Anaesthetized sheep had 33% of their total blood volume collected into Leukotrap bags (Pall Medical), which were processed into packed red blood cells and cross-matched for transfusion into other sheep. After 30 mins, the sheep were resuscitated with either: fresh (<5 days old) or stored (35-42 days old) ovine blood followed by 4% albumin to replacement volume, albumin alone or normal saline alone and monitored for 4 h. RESULTS: The first hit of haemorrhage precipitated substantial decreases in mean arterial pressure however haemostasis was preserved. Transfusion of stored ovine blood induced (1) transient pulmonary arterial hypertension but no oedema and (2) reduced fibrinogen levels more than fresh blood, but neither induced coagulopathy. Thus, transfusion of stored blood affected pulmonary function even in the absence of overt organ injury. CONCLUSION: The fact that stored blood transfusions: (1) did not induce acute lung injury in contrast to previous lipopolysaccharide-primed animal models identifies the 'first hit' as an important determinant of the severity of transfusion-mediated injury; (2) impaired pulmonary dynamics verifies the sensitivity and vulnerability of the pulmonary system to injury.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Tung, Y.P.
(författare)
-
Foley, S.R.
(författare)
-
Simonova, G.
(författare)
-
Thom, O
(författare)
-
Staib, A
(författare)
-
Collier, J
(författare)
-
Dunster, K.R.
(författare)
-
Solano, C
(författare)
-
Shekar, K
(författare)
-
Chew, MichelleLund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups(Swepub:lu)anes-mch
(författare)
-
Fraser, J F
(författare)
-
Anestesiologi och intensivvårdForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Vox Sanguinis: Wiley105:2, s. 150-1581423-04100042-9007
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Fung, Y.L.
-
Tung, Y.P.
-
Foley, S.R.
-
Simonova, G.
-
Thom, O
-
Staib, A
-
visa fler...
-
Collier, J
-
Dunster, K.R.
-
Solano, C
-
Shekar, K
-
Chew, Michelle
-
Fraser, J F
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Vox Sanguinis
- Av lärosätet
-
Lunds universitet