Sökning: onr:"swepub:oai:lup.lub.lu.se:66b2fb5f-cc51-4e91-88c2-221610dcc797" > Haplotypes of the e...
Fältnamn | Indikatorer | Metadata |
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000 | 04749naa a2200793 4500 | |
001 | oai:lup.lub.lu.se:66b2fb5f-cc51-4e91-88c2-221610dcc797 | |
003 | SwePub | |
008 | 160401s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11438472 URI |
024 | 7 | a https://doi.org/10.1002/ijc.231272 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Cox, David G4 aut |
245 | 1 0 | a Haplotypes of the estrogen receptor beta gene and breast cancer risk |
264 | c 2007-10-12 | |
264 | 1 | b Wiley,c 2008 |
520 | a Exposure to exogenous (oral contraceptives, postmenopausal hormone therapy) and endogenous (number of ovulatory cycles, adiposity) steroid hormones is associated with breast cancer risk. Breast cancer risk associated with these exposures could hypothetically be modified by genes in the steroid hormone synthesis, metabolism and signaling pathways. Estrogen receptors are the first step along the path of signaling cell growth and development upon stimulation with estrogens. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium has systematically selected haplotype tagging SNPs in genes along the steroid hormone synthesis, metabolism and binding pathways, including the estrogen receptor beta (ESR2) gene. Four htSNPs tag the 6 major (>5% frequency) haplotypes of the ESR2 gene. These polymorphisms have been genotyped in 5,789 breast cancer cases and 7,761 controls nested within the American Cancer Society Cancer Prevention Study II, European Prospective Investigation into Cancer and Nutrition, Multiethnic Cohort, Nurses' Health Study and Women's Health Study cohorts. None of the SNPs were independently associated with breast cancer risk. One haplotype of the ESR2 gene was associated with breast cancer risk before correction for multiple testing (OR 1.17, 95% CI 1.07-1.28, p = 0.0007). This haplotype remained associated with breast cancer risk after adjustment for multiple testing using a permutation procedure. There was no statistically significant heterogeneity in SNP or haplotype odds ratios across cohorts. These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a risk | |
653 | a haplotype | |
653 | a polymorphism | |
653 | a breast cancer | |
653 | a estrogen receptor beta | |
700 | 1 | a Bretsky, Philip4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Pharoah, Paul4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Amiano, Pilar4 aut |
700 | 1 | a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Buring, Julie4 aut |
700 | 1 | a Burtt, Noel4 aut |
700 | 1 | a Calle, Eugenia E4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Chanock, Stephen4 aut |
700 | 1 | a Clavel-Chapelon, Françoise4 aut |
700 | 1 | a Colditz, Graham A4 aut |
700 | 1 | a Spencer Feigelson, Heather4 aut |
700 | 1 | a Haiman, Christopher A4 aut |
700 | 1 | a Hankinson, Susan E4 aut |
700 | 1 | a Hirschhorn, Joel4 aut |
700 | 1 | a Henderson, Brian E4 aut |
700 | 1 | a Hoover, Robert4 aut |
700 | 1 | a Hunter, David J4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Kolonel, Laurence4 aut |
700 | 1 | a LeMarchand, Loic4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Peeters, Petra H M4 aut |
700 | 1 | a Pike, Malcolm C4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Stram, Daniel O4 aut |
700 | 1 | a Thun, Michael4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Yeager, Meredith4 aut |
710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t International Journal of Cancerd : Wileyg 122:2, s. 387-392q 122:2<387-392x 0020-7136 |
856 | 4 | u http://dx.doi.org/10.1002/ijc.23127y FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.23127 |
856 | 4 8 | u https://lup.lub.lu.se/record/1143847 |
856 | 4 8 | u https://doi.org/10.1002/ijc.23127 |
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