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Association of veno...
Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis : A multinational study
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- Moiseev, Sergey (författare)
- I.M. Sechenov First Moscow State Medical University,Lomonosov Moscow State University
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- Kronbichler, Andreas (författare)
- Medical University of Innsbruck
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- Makarov, Egor (författare)
- Lomonosov Moscow State University
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- Bulanov, Nikolay (författare)
- I.M. Sechenov First Moscow State Medical University
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- Crnogorac, Matija (författare)
- Dubrava University Hospital
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- Direskeneli, Haner (författare)
- Marmara University
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- Galesic, Kresimir (författare)
- University Hospital of Infectious Diseases
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- Gazel, Ummugulsum (författare)
- Marmara University
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- Geetha, Duvuru (författare)
- Johns Hopkins University
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- Guillevin, Loic (författare)
- Cochin Hospital
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- Hrušková, Zdenka (författare)
- General University Hospital in Prague,Charles University in Prague
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- Little, Mark A. (författare)
- Trinity Translational Medicine Institute,Tallaght University Hospital
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- Ahmed, Adeel (författare)
- Beaumont Hospital, Dublin
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- McAdoo, Stephen P. (författare)
- Imperial College London
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- Mohammad, Aladdin J. (författare)
- Skåne University Hospital,Addenbrooke's Hospital
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- Moran, Sarah (författare)
- Trinity Translational Medicine Institute
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- Novikov, Pavel (författare)
- I.M. Sechenov First Moscow State Medical University
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- Pusey, Charles D. (författare)
- Imperial College London
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- Rahmattulla, Chinar (författare)
- Leiden University Medical Centre
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- Satrapová, Veronika (författare)
- General University Hospital in Prague,Charles University in Prague
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- Silva, Joana (författare)
- Imperial College London
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- Terrier, Benjamin (författare)
- Cochin Hospital
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- Tesař, Vladimír (författare)
- Charles University in Prague,General University Hospital in Prague
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- Westman, Kerstin (författare)
- Lund University,Lunds universitet,Autoimmunitet och njursjukdomar,Forskargrupper vid Lunds universitet,Autoimmunity and kidney diseases,Lund University Research Groups
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- Jayne, David R.W. (författare)
- University of Cambridge
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IM. Sechenov First Moscow State Medical University Lomonosov Moscow State University (creator_code:org_t)
- 2021-02-01
- 2021
- Engelska 8 s.
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Ingår i: Rheumatology. - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 60:10, s. 4654-4661
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods: Patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation were included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, were collected retrospectively from tertiary vasculitis centres. Univariate and multivariate regression models were used to estimate odds ratios (ORs) and 95% CIs. Results: Over a median follow-up of 63 (interquartile range: 29, 101) months, VTE occurred in 278 (9.7%) of 2869 AAV patients with a similar frequency across different countries (from 6.3% to 13.7%), and AAV subtype [granulomatosis with polyangiitis: 9.8% (95% CI: 8.3, 11.6%); microscopic polyangiitis: 9.6% (95% CI: 7.9, 11.4%); and eosinophilic granulomatosis with polyangiitis: 9.8% (95% CI: 7.0, 13.3%)]. Most VTE (65.6%) were reported in the first-year post-diagnosis. Multiple factor logistic regression analysis adjusted for sex and age showed that skin (OR 1.71, 95% CI: 1.01, 2.92), pulmonary (OR 1.78, 95% CI: 1.04, 3.14) and kidney [eGFR 15-60 ml/min/1.73 m2, OR 2.86 (95% CI: 1.27, 6.47); eGFR <15 ml/min/1.73 m2, OR 6.71 (95% CI: 2.94, 15.33)] involvement were independent variables associated with a higher occurrence of VTE. Conclusion: Two-thirds of VTE occurred during the initial phase of active disease. We confirmed previous findings from smaller studies that a decrease in kidney function, skin involvement and pulmonary disease are independently associated with VTE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- ANCA-associated vasculitis
- Risk factors
- Venous thromboembolic events
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Moiseev, Sergey
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Kronbichler, And ...
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Makarov, Egor
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Bulanov, Nikolay
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Crnogorac, Matij ...
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Direskeneli, Han ...
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visa fler...
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Galesic, Kresimi ...
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Gazel, Ummugulsu ...
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Geetha, Duvuru
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Guillevin, Loic
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Hrušková, Zdenka
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Little, Mark A.
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Ahmed, Adeel
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McAdoo, Stephen ...
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Mohammad, Aladdi ...
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Moran, Sarah
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Novikov, Pavel
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Pusey, Charles D ...
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Rahmattulla, Chi ...
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Satrapová, Veron ...
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Silva, Joana
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Terrier, Benjami ...
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Tesař, Vladimír
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Westman, Kerstin
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Jayne, David R.W ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Rheumatology
- Av lärosätet
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Lunds universitet